Megaloblastic Anemia
Abstract Megaloblastic anemias are characterized by the presence of megaloblasts in the bone marrow and macrocytes in the blood. In more than 95% of cases, megaloblastic anemia is a result…
Bone Marrow Failure
Abstract This chapter describes the causes, clinical manifestations, diagnosis and treatment of various types of both acquired and inherited bone marrow failure syndromes. Keywords Diamond–Blackfan anemia (DBA), Fanconi anemia (FA),…
Anemia During the Neonatal Period
Abstract Anemia during the neonatal period is caused by: (i) Hemorrhage : acute or chronic, (ii) Hemolysis : congenital hemolytic anemias or due to isoimmunisation, and (iii) Failure of red…
Iron-Deficiency Anemia
Abstract Iron deficiency is the most common nutritional deficiency in children and is worldwide in distribution, affecting 2 billion people. The prevalence of iron deficiency worldwide is twice as high…
Lymphadenopathy and Diseases of the Spleen
Abstract Lymphadenopathy and splenomegaly are common findings in children. Both benign and malignant processes can produce these findings and it is important to distinguish between the two so that appropriate…
Classification and Diagnosis of Anemia in Children
Abstract Anemia can be defined as a reduction in hemoglobin concentration, hematocrit, or number of red blood cells per cubic millimeter. The lower limit of the normal range is set…
Hematologic Manifestations of Systemic Illness
Abstract A variety of systemic illnesses including acute and chronic infections, neoplastic diseases, connective tissue disorders, and storage diseases are associated with hematologic manifestations. Keywords Systemic illness, hematology, iron deficiency,…
Diagnostic Molecular and Genomic Methodologies for the Hematologist/Oncologist
Abstract Over the past several years, molecular diagnostic testing in patients with hematologic and oncologic disorders has become increasingly sophisticated and prevalent. While in the past focused genetic tests were…
