Autologous and allogeneic hematopoietic cell transplantation (HCT) is regularly used as a curative treatment option for patients with various disorders, including acute leukemia in adults. The past decade has witnessed…
Most adult patients with acute lymphoblastic leukemia (ALL) will die of the disease. The prognosis in all patients with relapsed or refractory disease is uniformly poor. Although allogeneic hematopoietic stem…
Approximately half of all adults with acute lymphoblastic leukemia now survive long term. This article summarizes the current approaches to treating acute lymphoblastic leukemia in adults, with a focus on…
The introduction of all -trans retinoic acid to anthracycline-based chemotherapy has revolutionized the prognosis of patients with acute promyelocytic leukemia (APL). The introduction of arsenic trioxide enabled the therapeutic approach…
Historically, acute leukemias that do not fit neatly into the broad categories of “acute myeloid leukemia” or “acute lymphoblastic leukemia” have caused considerable confusion and frustration for clinicians and pathologists….
The prognostic factors in adult acute leukemia have undergone a major change over the past decade and are likely to be further refined in the coming years. Age is the…
Advances in the understanding of the molecular pathogenesis of acute myeloid leukemia have led to the identification of diagnostic and prognostic markers, resulting in further refinement of karyotype-based risk classification….
The last 4 decades have seen major advances in understanding the genetic basis of acute myeloid leukemia (AML), and substantial improvements in survival of children and young adults with the…
Increased understanding of the molecular genetics of acute myeloid leukemia (AML) has uncovered several mutations in genes with a role in the epigenetic regulation of gene transcription, including mutations in…
Martin S. Tallman, MD, Guest Editor The acute leukemias represent a heterogeneous group of malignant hematopoietic stem cell disorders with myeloid characteristics. Remarkable insights have occurred in our understanding of…
