FIGURE 145-1. Cartoon illustrating the cascade on transcription factor genes programming hypothalamic and pituitary embryogenesis and function. Most of this information was derived from genetic studies in mice. The list…
FIGURE 13-1. Standard mortality rates (SMR) and 95% confidence intervals (CI) in individual studies on patients with nonmalignant pituitary diseases not associated with excess adrenocorticotropic hormone (ACTH) or growth hormone…
FIGURE 109-1. A, Anatomic distribution of extra-adrenal chromaffin tissue in the newborn. B, Locations of extra-adrenal pheochromocytomas reported in the literature up to 1965. (From Coupland R: The Natural History…
FIGURE 139-1. A, An 18-year-old male with isolated hypogonadotropic hypogonadism. Note the normal height, long arms and legs, poor muscular development, and prominent gynecomastia. Although his testes and phallus are…
The mechanism whereby the POMC gene becomes derepressed in noncorticotroph tumors is not understood. One hypothesis is that these cells are derived from a common multipotential progenitor cell capable of…
FIGURE 131-1. Left panel, Cumulative conception rates during the first 12 months of unprotected intercourse. Right panel, Probability of a clinical pregnancy relative to the day of intercourse. Day 0…
FIGURE 153-1. Schematic illustration of tryptophan metabolism in a neuroendocrine cell (enterochromaffin [EC]-cell). CLASSIFICATION Carcinoid tumors have been traditionally classified according to their embryonic origin into foregut, midgut, or hindgut…
FIGURE 107-1. Schematic representation of the renin-angiotensin-aldosterone system in primary aldosteronism. Aldosterone secretion is increased independently of the renin-angiotensin system. Aldosterone increases sodium (Na+) reabsorption at the renal cortical collecting…
FIGURE 62-1. Radiologic representation of osteitis fibrosa cystica in classic primary hyperparathyroidism. A, Salt-and-pepper skull. B, Cystic bone disease of the clavicle. C, Subperiosteal bone resorption of the digits. D,…
FIGURE 45-1. Cumulative incidence of further progression of retinopathy during the Epidemiology of Diabetes Interventions and Complications (EDIC) study in the former conventional therapy and intensive therapy cohorts from the…
