Neurobiology of Older Age Bipolar Disorder
Fig. 3.1 Imaging from research has shown decrease in the volume of gray matter in patients with bipolar disorder in the right cudate, globus palidus, lateral ventricles, insula, and amygdale. White…
Epidemiology of Older Age Bipolar Disorder
An adult >age 50 with Early-onset bipolar disorder = Older age bipolar disorder Early-onset depressive disorder with new-onset mania New-onset mania in individual with no prior mood illness (in the absence…
Treatment Settings for Older Age Bipolar Disorder: Inpatient, Partial Hospitalization, Outpatient, Models of Integrated Care
© Springer International Publishing AG 2017Susan W. Lehmann and Brent P. Forester (eds.)Bipolar Disorder in Older Age Patients10.1007/978-3-319-48912-4_11 11. Treatment Settings for Older Age Bipolar Disorder: Inpatient, Partial Hospitalization, Outpatient, Models of Integrated Care Colin Depp1 …
Complementary and Integrative Therapies for Older Age Bipolar Disorder
Intervention Mechanism of action Effectiveness in bipolar disorder Adverse effects/notable interactions Omega-3 fatty acids Regulation of neurotransmission, involved in cell survival and protection against neuro-inflammation Mixed evidence for mild–moderate effect…
Cognitive Impairment and Older Age Bipolar Disorder
Fig. 6.1 Potential interactive and non-interactive effects of age and bipolar disease (used with permission from Weisenbach et al. [4]) In their cross-sectional study of young and late middle-aged patients with…
Psychotherapy and Psychosocial Interventions, Family Psychoeducation, and Support for Older Age Bipolar Disorder
Articles Groups RCT Total N Mean age Sample description Recruitment Attrition Bartels et al. [20], Mueser et al. [21] (same sample) HOPES versus TAU Yes 183 60.2 20 % BD, 28 %…
Neuromodulation Therapies and Ketamine in Older Age Bipolar Disorder
Modulation therapy General anesthesia Cognitive side effects Indicated when failure to respond to one antidepressant in current episode Treatment-resistant depression Switch to mania Seizurogenic ECT Yes Yes – + Cases reported…
Clinical Assessment of Older Adults with Bipolar Disorder
Neurological Dementia/neurocognitive disorders Traumatic brain injury Epilepsy Infectious encephalitis Cerebrovascular disease Brain tumors Movement disorders Systemic Infections Thyroid abnormalities Illicit Drugs: i.e., cocaine Medication Antidepressants Benzodiazepines Corticosteroids Thyroid replacements Dopamine…
Lithium in Older Age Bipolar Disorder
Age category (years) Target lithium levela (mmol/L) Approximate lithium daily doseb (mg/day) Starting doseb (mg/day) 45–59 0.4–0.8 600–1200 300–450 60–79 0.4–0.8 300–600 150 80–95 0.4–0.6 150–300 150 aThe target lithium…
Clinical Management of Older Age Bipolar Disorder
Increase No effect Decrease Lithium Loop diuretics Aspirin Mannitol Thiazide diuretics Paracetamol Aminophylline Calcium blockers Nefazodone Theophylline ACE inhibitors Mirtazepine AT II receptor blockers Valproate COX2 inhibitors Lamotrigine Trimethoprim Amisulpride…
