Discovery and Evaluation of Anticancer Drugs Aaron D. Schimmer and Ian F. Tannock 17.1 Introduction 17.2 Strategies to Develop Anticancer Drugs 17.2.1 Gene Expression and Identification of Potential Targets for…
Drug Resistance Susan P.C. Cole and Ian F. Tannock 19.1 Introduction 19.2 Causes of Cellular Drug Resistance 19.2.1 Molecular Mechanisms of Drug Resistance 19.2.2 Resistance Caused by Impaired Drug Uptake…
Cell Proliferation and Death Paul Jorgensen and Razqallah Hakem 9.1 Introduction 9.2 Molecular Control of Cell Proliferation 9.2.1 The Mammalian Cell Cycle 9.2.2 Molecular Mechanisms Central to Cell-Cycle Control 9.2.3…
Genomic Stability and DNA Repair Shane M. Harding, Robert G. Bristow, and Lea Harrington 5.1 Introduction 5.2 Genetic Instability as the Basis for Malignant Transformation 5.2.1 Intrinsic Causes of Genetic…
Cellular Signaling Pathways Michael Reedijk and C. Jane McGlade 8.1 Introduction 8.2 Growth Factor Signaling Pathways 8.2.1 Extracellular Growth Factors and Receptor Tyrosine Kinases 8.2.2 Formation of Multiprotein Complexes and…
Angiogenesis Janusz Rak 11.1 Introduction: The Tumor–Vascular Interface 11.2 Constituents of the Vascular System 11.2.1 Blood Vessel and Lymphatic Networks 11.2.2 Properties of Cells Involved in Vascular Structures 11.3 Processes Leading to…
Heterogeneity in Cancer: The “Cancer Stem Cell” Hypothesis Craig Gedye 13.1 Introduction: Can We Identify the Cancer Cells that Kill Patients? 13.2 Heterogeneity in Cancer 13.2.1 Stromal Heterogeneity in Cancer…
Tumor Progression and Metastasis Yang W. Shao, Rama Khokha, and Richard P. Hill 10.1 Tumor Progression 10.1.1 Cellular Aspects of Tumor Progression 10.1.2 Molecular Genetics of Tumor Progression 10.2 Tumor Microenvironment 10.2.1 Extracellular…
Chemical Carcinogenesis Denis M. Grant 4.1 Introduction and Historical Perspective 4.2 Biology of Chemical Carcinogenesis 4.2.1 Tumor Initiation, Promotion, and Progression 4.2.2 Genetic Instability and the Hallmarks of Cancer 4.2.3…
Imaging in Oncology David A. Jaffray 14.1 Introduction 14.2 General Concepts Relating to Cancer Imaging 14.3 Imaging Technologies 14.3.1 X-ray–Based Systems: Radiography and Computed Tomography 14.3.2 Magnetic Resonance Imaging 14.3.3…
