Tumor and Normal Tissue Response to Radiotherapy Richard P. Hill and Robert G. Bristow 16.1 Introduction 16.2 Principles of Clinical Radiotherapy 16.2.1 Radiotherapy Dose 16.2.2 Radiotherapy Planning and Dose Delivery…
Methods of Molecular Analysis Anthony M. Joshua, Paul C. Boutros, and Thomas Kislinger 2.1 Introduction 2.2 Principal Techniques for Nucleic Acid Analysis 2.2.1 Cytogenetics and Karyotyping 2.2.2 Hybridization and Nucleic…
Cancer Epidemiology Gord Fehringer, Rayjean J. Hung, and Geoffrey Liu 3.1 Introduction and Terminology 3.1.1 Epidemiology: Definition and Scope 3.1.2 General Approach 3.1.3 Role of Epidemiology in Translational Medicine 3.2…
Molecular and Cellular Basis of Radiotherapy Shane M. Harding, Richard P. Hill, and Robert G. Bristow 15.1 Introduction 15.2 Interaction of Radiation with Matter 15.2.1 Types of Radiation, Energy Deposition,…
Pharmacology of Anticancer Drugs Eric X. Chen 18.1 General Principles of Pharmacology 18.1.1 Pharmacokinetics and Pharmacodynamics 18.1.2 Dosing of Chemotherapy in Individual Patients 18.1.3 Pharmacogenetics 18.2 Alkylating Agents 18.2.1 Nitrogen…
The Immune System and Immunotherapy Linh T. Nguyen, Evan F. Lind, and Pamela S. Ohashi 21.1 Introduction to the Immune System 21.2 Innate Immunity 21.2.1 Antigen Presentation 21.2.2 Maturation of…
Hormones and Cancer Paul S. Rennie, Eric Leblanc, and Leigh C. Murphy 20.1 Introduction 20.2 Basic Mechanisms of Hormone Action 20.2.1 Synthesis and Metabolism of Estrogens 20.2.2 Synthesis and Metabolism…
Guide to Clinical Studies Eitan Amir and Ian F. Tannock 22.1 Introduction 22.2 Treatment 22.2.1 Purpose of Clinical Trials 22.2.2 Sources of Bias in Clinical Trials 22.2.3 Importance of Randomization…
Tumor Growth, Microenvironment, and Metabolism Rob A. Cairns, Ian F. Tannock, and Bradly Wouters 12.1 Tumor Growth and Cell Kinetics 12.1.1 Growth of Human Tumors 12.1.2 Cell-Cycle Analysis 12.1.3 Cell…
Oncogenes and Tumor-Suppressor Genes Previn Dutt and Vuk Stambolic 7.1 Introduction 7.2 The Genetic Basis of Cancer 7.2.1 Historical Perspective 7.2.2 Transforming Retroviruses 7.2.3 The Knudson Two-Hit Hypothesis 7.2.4 Discovery…
