Efavirenz

Aug 11, 2016 by in INFECTIOUS DISEASE Comments Off on Efavirenz

Chapter 14 Efavirenz Schlomo Staszewski, MD Efavirenz (EFV, Sustiva) is a human immunodeficiency virus type 1 (HIV-1) specific, non-nucleoside reverse transcriptase inhibitor (NNRTI). EFV is a noncompetitive inhibitor of HIV-1…

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Kaposi Sarcoma

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Chapter 59 Kaposi Sarcoma Susan E. Krown, MD Kaposi sarcoma (KS) was one of the first opportunistic diseases described in association with the acquired immune deficiency syndrome (AIDS).1 Despite a…

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Mycoses Caused by Molds

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Chapter 47 Mycoses Caused by Molds Thomas F. Patterson, MD, John R. Graybill, MD Infections caused by molds are uncommon but important causes of opportunistic infections in patients with advanced…

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Fosamprenavir and Amprenavir

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Chapter 19 Fosamprenavir and Amprenavir Roger Paredes, MD, Lidia Ruiz, PhD, Bonaventura Clotet, MD, PhD INTRODUCTION Protease inhibitors (PIs) are one of the mainstays of HIV/AIDS therapy,1 being largely responsible…

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Cryptococcosis

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Chapter 43 Cryptococcosis Judith A. Aberg, MD, William G. Powderly, MD Disseminated cryptococcosis has been the most common life-threatening fungal infection in patients with acquired immunodeficiency syndrome (AIDS), affecting up…

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Lopinavir

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Chapter 20 Lopinavir Steven C. Johnson, MD, Daniel R. Kuritzkes, MD Lopinavir (formerly known as ABT-378) was the first of the ‘second-generation’ protease inhibitors (PIs) to be approved for clinical…

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Herpes Simplex Virus Infections

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Chapter 48 Herpes Simplex Virus Infections Kimberly Y. Smith, MD, MPH, Harold A. Kessler, MD PATHOGEN Herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) are common pathogens in…

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Saquinavir

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Chapter 15 Saquinavir Anton Posniak, MD, FRCP, Kasha P. Singh, MBBS, FRACP INTRODUCTION On the 4 December 1997, the Society for Medicines Research Award for Drug Discovery was presented to…

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Coccidioidomycosis

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Chapter 45 Coccidioidomycosis Neil M. Ampel, MD INTRODUCTION Coccidioidomycosis is an infection caused by the dimorphic fungus Coccidioides. The endemic region for this mycosis is confined to the Western hemisphere…

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Drug Interactions and Administration

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Chapter 79 Drug Interactions and Administration Charles Flexner, MD, Paul A. Pham, PharmD Pharmacology plays a critical role in the treatment of HIV infection affecting issues as diverse as adherence,…

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