Chapter 25 Tipranavir Véronique Joly, MD, Patrick Yeni, MD INTRODUCTION The availability of potent antiretroviral drugs, including protease inhibitors (PI), and their use in combination regimens–highly active antiretroviral therapy (HAART)–has…
Chapter 70 HIV-Related Renal Disease Jonathan A. Winston, MD, Paul E. Klotman, MD Diseases of the kidney are generally classified into one of two broad clinical syndromes, acute renal failure…
Chapter 75 Bone Disorders Val Amorosa, MD, Pablo Tebas, MD OSTEOPOROSIS Introduction Osteoporosis is a disease characterized by low bone mass and microarchitectural deterioration of bone tissue, leading to enhanced…
Chapter 44 Histoplasmosis Lawrence J. Wheat, MD INTRODUCTION Histoplasmosis is a serious opportunistic infection in patients with acquired immunodeficiency syndrome (AIDS) in endemic regions of America, Africa, and Asia, although…
Chapter 24 Inhibiting the Entry of R5 and X4 HIV-1 Phenotypic Variants Shawn E. Kuhmann, PhD, Roy M. Gulick, MD, MPH, John P. Moore, PhD Compounds that prevent HIV-1 from…
Chapter 74 Lactic Acidosis and Other Mitochondrial Disorders Associated with HIV Therapy David Nolan, MD, Simon Mallal, MD INTRODUCTION Nucleoside analog reverse transcriptase inhibitors (NRTI) were the first class of…
Chapter 46 Candidiasis Carl J. Fichtenbaum, MD, Peter G. Pappas, MD INTRODUCTION Oropharyngeal candidiasis (OPC) was among the initial manifestations recognized in association with human immunodeficiency virus (HIV) infection,1,2 affecting…
Chapter 58 Sexually Transmitted Infections Lara B. Strick, MD MSc, Christina M. Marra, MD, Connie L. Celum, MD, MPH INTRODUCTION The importance of the bidirectional relationship between human immunodeficiency virus…
Chapter 72 Lipid Disorders Peter Reiss, MD, PhD, Marc van der Valk, MD, PhD INTRODUCTION The use of highly active antiretroviral therapy (HAART)1–3 is frequently associated with side effects. Among…
Chapter 35 Managing Pregnant Patients James McIntyre, FRCOG INTRODUCTION The AIDS epidemic continues to affect many millions of people globally. UNAIDS estimated that there were 39.5 million people living with…
