Central Venous Access for Chemotherapy Michael B. Nicholl Paul S. Dale Despite remarkable achievements in cancer prevention, detection, and treatment, cancer is still the second leading cause of death in…

Gonadal Complications and Teratogenicity of Cancer Therapy Catherine E. Klein Sonia Okuyama In recent years, the remarkable screening, diagnostic, and therapeutic advances in the practice of oncology have totally altered…

Chemotherapy in Pregnancy Monique A. Hartley-Brown Donald C. Doll Cancer during pregnancy is fairly uncommon. It is the leading cause of death in women of childbearing age with an incidence…

Second Malignancies after Chemotherapy Daniel J. Becker Thomas S. Uldrick Alfred I. Neugut The era of modern chemotherapy traces back to the 1940s when it was discovered that the nitrogen…

Vascular Toxicity of Antineoplastic Agents Ravi K. Bobba Donald C. Doll The association of venous thromboembolism (VTE) with underlying malignancy is well known; thereby screening for an occult malignancy in…

Chemotherapy-Induced Peripheral Neuropathy Frederick Hausheer Stacey Bain Chemotherapy-induced peripheral neuropathy (CIPN) is a common and serious clinical problem that affects many patients receiving cancer treatment.1,2,3,4 This iatrogenic condition can pose…

Chemotherapy-Induced Renal and Electrolyte Dysfunction Harbaksh Sangha Ramesh Khanna The chemotherapeutic drugs that are filtered, secreted, and cleared by the kidneys have the potential to cause acute and chronic kidney…

Hepatotoxicity of Chemotherapeutic Agents Ravi K. Bobba Stephen Medlin Michael C. Perry The development of abnormal liver function tests (LFTs) in a patient who is receiving chemotherapy can present a…

Gastrointestinal Complications of Chemotherapy Rashmi Ramasubbaiah Gastrointestinal (GI) side effects are very common with most chemotherapeutic and targeted agents (biologics). Most experts feel that the toxicities are generally underreported.1,2,3 It…

Pulmonary Toxicity of Chemotherapeutic Agents Vamsi P. Guntur Rajiv Dhand Pulmonary toxicity is recognized with a growing number of chemotherapeutic agents. An estimated 5% to 20% or more of patients…