Fig. 7.1 Barium esophagogram of a patient with esophageal cancer shows abrupt narrowing of esophagus and focal areas of ulceration (arrow) with stricture Staging Clinical staging tools include esophagoscopy with…
Fig. 3.1 Structural layers of the esophagus. (a) H&E stain. The innermost layer (or tunica) is the mucosa. The mucosa is composed of an epithelial lining (squamous epithelium), the underlying…
Reference Year Path Arm N OS MS pCR RT Chemo [33] 1988–1991 SCC 100 % S CRT 45 41 3y 14 % 3y 19 % NS 11 m 10.5 m…
Study No. of patients Radiation dose (Gy) Chemotherapy 2-year survival (%) Araujo et al. [44] 28 50 None 22 31 50 5-FU, MMC, Bleo 38 Smith et al. [45] 62…
Fig. 2.1 Histological features of esophageal cancer prepared by formalin fixation and paraffin embedding reveal a well-differentiated squamous cell carcinoma with good histological detail In recent years, the use of…
Study Design N RR (%) PFS (months) OS (months) References Cisplatin-based combinations CF vs. C Phase II 88 35 vs. 19 TTP: 27 vs. 18 weeks 2 years: 18 vs….
Treatment Histology No. of patients R0 resection rate Pathologic CR rate Survival Local failure References Median Overall Periop ECF + surgery Adeno 250 69 % 0 % 24 months 5 years 36 %…
© Springer International Publishing Switzerland 2015Nabil F. Saba and Bassel F. El-Rayes (eds.)Esophageal Cancer10.1007/978-3-319-20068-2_9 9. Principles and Approaches in Surgical Resection of Esophageal Cancer Nabil Pierre Rizk1 (1) Thoracic Surgery, Memorial Sloan Kettering Cancer Center, New York,…
Benefits Risks Reduced cardiovascular risk (RR approx. 0.75) Increased risk of GI hemorrhage (<100 mg/day 0.3 %/year vs. 1.1 % with >325 mg/day) Reduced risk of GI cancers Increased risk…
Fig. 11.1 Histone acetylation. HA Histone acetylation, HAT Histone acetyltransferases, HDAC Histone deacetylases 11.1.4 Histone Methylation Histone Methylation (HM) also occurs at lysine-(K) and arginine-(R) residues without changing the chromatic…
