Fig. 16.1 The altered peptide/major histocompatibility complex class I (pMHCI) repertoire caused by antigen-processing defect (APD). In ERAAP-deficient or tapasin-deficient cells, the total amount of pMHCI on the cell surface…
Diseases Number of patients Results Effect of apilimod on cytokine production Ref. Crohn’s disease 73 Significant Burakoff et al. (2006) Crohn’s disease Significant Billich (2007) Crohn’s disease 220 Not significant …
Peptide dose Number of cases RECIST evaluationa Decreased tumor marker PIVKA-II CTL frequencyb 0.3 mg 8 SD 3, PD 5 0/8 (0 %) 7.5 1.0 mg 6 SD 4, PD…
Fig. 13.1 Invariant natural killer T (iNKT) cell-mediated adjuvant effects on T cells are dependent on the innate immunity. Intravenously administered artificial adjuvant vector cells (aAVCs) are killed by iNKT…
Fig. 7.1 Classification of CLRs by intracellular signaling motifs. Representative CLRs are classified based on their intracellular signaling motifs: ITAM-containing receptors (such as Dectin-1, CLEC2, CLEC9A, and SIGN-R3), adaptor-recruiting receptors…
Year Author No. of patients Setting for DCs Responses 2002 Ladhams et al. 2 GM-CSF/IL-4 DC + tumor 1/2 inhibition of tumor growth 2003 Iwashita et al. 10 GM-CSF/IL-4 DC + tumor lysate + TNF-α + KLH 1/10…
History Parameter Action Age/family history Obesity BMI Avoid further gain, gradual loss Diabetes HbA1C/Fasting glucose Initiate diabetic therapy Inactivity Minutes of recreational physical activity/week Encourage 150 min or more recreational…
Fig. 17.1 Conceptual framework for receipt of optimal cancer care (Adapted from Shavers and Brown, JNCI 2002 with permission) After the initial treatment decisions are made, and treatments are underway,…
Physical and medical challenges Managing physical symptoms and side effects (e.g., pain, fatigue) Dealing with constant or changing treatment schedules Accepting stable disease as a desirable outcome of treatment Maintaining…
Fig. 3.1 Projected cases of all invasive cancers in the United States by age and sex [Reproduced with permission from Smith et al. (2009)] Although breast cancer is associated with…
