Anemia Zuzana Tothova, James Bradner INTRODUCTION Anemia is defined as a decrease in the red blood cell mass circulating in the bloodstream, and derives from an imbalance in the production…

Localized Breast Cancer Beverly Moy Breast cancer is considered “localized” if it is technically possible to excise cancerous tissue, if the tumor does not involve the skin or structures deep…

Mantle Cell Lymphoma Dan L. Longo Mantle cell lymphoma is neoplasm derived from B cells that normally occupy the mantle zone surrounding the lymphoid follicle. Mantle cell lymphomas account for…

Interferons Dan L. Longo The interferons (IFNs) are a family of proteins that are grouped into three classes α, β, and γ. They were discovered based on their ability to…

Chronic Myeloid Leukemia Karen Ballen ETIOLOGY AND EPIDEMIOLOGY Chronic myeloid leukemia (CML) is a clonal disorder of the hematopoietic stem cell affecting every lineage (except T lymphocytes). It affects about…