Genetic Mouse Models of Cancer
Figure 9-1 Non–genetically engineered mouse models of cancer (A,B) Mice develop tumors spontaneously or in response to carcinogen exposure. (C,D) Transplantation of human or mouse tumor cells into recipient mice…
ONCOLOGY
The Biology of Primary Brain Tumors
Molecular Biology of the Most Common Primary Central Nervous System Tumors Brain tumors are thought to arise as the result of genetic and epigenetic alterations that activate oncogenes and inactivate…
High-Content Analysis with Cellular and Tissue Systems Biology
Figure 25-1 Solid tumors are systems within the human system The tumor system includes normal tissue/organ cells (pink), tumor cells usually containing a range of genetic alterations (yellow), and cancer…
Molecular Pathogenesis of Pancreatic Adenocarcinoma
Figure 35-1 Pancreatic epithelial neoplasia and the multistep model of exocrine pancreatic cancer. (From Maitra A, Adsay NV, Argani P, et al. Multicomponent analysis of the pancreatic adenocarcinoma progression model…
Animal Models
Figure 8-1 Model organisms (the budding yeast—Saccharomyces cerevisiae; the fruit fly—Drosophila melanogaster; and the zebrafish—Danio rerio) and their key attributes as models for dissecting the molecular basis of cancer. Forward…
Cancer Chemoprevention
5-LOX, 5-Lipoxygenase; CDK, cyclin-dependent kinase; DFMO, difluoromethylornithine; EGFR, epidermal growth factor receptor; ER, estrogen receptor; FGFR, fibroblast growth factor receptor; HIF-1α, hypoxia-inducible factor-1 alpha; IGF-1R, insulin-like growth factor-1 receptor; MEK,…
Soft Tissue Sarcomas
t(1:13)(p36;q14) PAX3-FOXO1A PAX7-FOXO1A Alveolar soft-part sarcoma t(X;17)(p11;q25) TFE3-ASPL Angiomatoid fibrous histiocytoma t(12;16)(q13;p11) CREB1-EWSR1 ATF1-FUS Clear cell sarcoma t(12;22)(q13;q12) ATF1-EWSR1 CREB1-EWSR1 Dermatofibrosarcoma protuberans t(17;22)(q22;q13) PDGFB- COL1A1 Desmoplastic small round cell tumor…
Understanding and Using Information about Cancer Genomes
Figure 24-1 Schematic illustrations of the types of genome aberrations found in human cancers. 18 Table 24-1 Cancer Gene Census Summary Aberration Type Number of Aberrations Examples of Prominent Affected…
Molecular Genetics of Acute Lymphoblastic Leukemia
Figure 26-1 Kaplan-Meier analysis of overall survival in 2628 children with newly diagnosed acute lymphocytic leukemia (ALL). The patients participated in 15 consecutive studies conducted at St. Jude Children’s Research…
Cancer Systems Biology
Figure 20-1 Genomic alterations in glioma co-segregate with only some of the identified molecular subtypes. (With permission from Verhaak RG, Hoadley KA, Purdom E, et al. Integrated genomic analysis identifies…
