ONCOLOGY

The microbiome and cancer immunotherapy

Aug 6, 2023 by in ONCOLOGY Comments Off on The microbiome and cancer immunotherapy

Summary of key facts • The human microbiota is composed of bacteria, viruses, fungi, yeast, protozoa, and archaea. Because of its commensal relationship with the host, it is identified as…

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Vaccines and active immunization against cancer

Aug 6, 2023 by in ONCOLOGY Comments Off on Vaccines and active immunization against cancer

Summary of key facts • Cancer vaccines represent a promising strategy to activate immunity in cold tumors. • The complexity and heterogeneity of human tumors remains a challenge to developing…

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Tumor immune surveillance

Aug 6, 2023 by in ONCOLOGY Comments Off on Tumor immune surveillance

Summary of key facts • The concept of tumor immunosurveillance can be traced back to the early 1900s in association with observations that a potentially overwhelming frequency of carcinomas must…

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Cancer—avoiding immune detection

Aug 6, 2023 by in ONCOLOGY Comments Off on Cancer—avoiding immune detection

Summary of key facts • The natural history of a human malignancy and its relationship to the host immune system has been described as comprising the “three Es”: elimination, equilibrium,…

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Tumor antigenicity and cancer as non-self

Aug 6, 2023 by in ONCOLOGY Comments Off on Tumor antigenicity and cancer as non-self

Summary of key facts • Professor Paul Ehrlich is credited with introducing the concept of cancers as non-self and proposing the concept of tumor immune surveillance in 1909. • Evidence…

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Cancer and the science of innate immunity

Aug 6, 2023 by in ONCOLOGY Comments Off on Cancer and the science of innate immunity

Summary of key facts • The innate immune system is the host’s first line of immune defense against challenges of the environment. • The innate immune system response is a…

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Development and structure of the lymphoid system

Aug 6, 2023 by in ONCOLOGY Comments Off on Development and structure of the lymphoid system

Summary of key facts • The lymphatic system is a complex, blind-ended vascular tree distinct and separate from the blood circulatory system. • Lymphatics facilitate tissue fluid homeostasis, nutrient uptake,…

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