© Springer International Publishing Switzerland 2017Wojciech Golusiński, C. René Leemans and Andreas Dietz (eds.)HPV Infection in Head and Neck CancerRecent Results in Cancer Research20610.1007/978-3-319-43580-0_18 Predictive Factors for Outcome and Quality of Life in HPV-Positive and…
© Springer International Publishing Switzerland 2017Wojciech Golusiński, C. René Leemans and Andreas Dietz (eds.)HPV Infection in Head and Neck CancerRecent Results in Cancer Research20610.1007/978-3-319-43580-0_13 Should We De-escalate the Treatment for HPV-Positive Tumors? Andreas Dietz1, 2 , Gunnar Wichmann1,…
Fig. 1 NTCP values (risk on side effects) according to the 6 different approaches. CRT-70 current standard chemoradiation; BioRT-70 standard radiotherapy with cetuximab; CRT-56 reduced radiation dose chemoradiation; CPT-70 standard radiation…
Study Method Tested Positive (%) Citation SPECTRUM P16 443 99 (22 %) Vermorken et al., Lancet Oncol (2013) EXTREME P16 381 41 (12 %) Vermorken et al., Ann Oncol (2014) EXTREME HPV…
Authors Year No.pts Subsite % HPV Treatment HR Gillison et al. 2000 252 H&N 25 Surg a/o RT 0.40 Licitra et al. 2006 90 OPC 19 Surg ± RT 0.26 Fakhry et…
Fig. 1 HPV-attributable fractions for head and neck cancers according to positivity and/or over-expression of selected biomarkers of HPV-induced carcinogenesis Figure 2 shows oropharyngeal HPV-AFs by geography, gender, age group, and year of…
Reference Lesion No. of cases Method HPV-positivity Types detected Syrjänen et al. (1983a, b, c, d) SCC 40 ICH 8/40 20 % Syrjänen et al. (1983a, b, c, d) SCC 1…
Fig. 1 a Schematic overview of HPV infection and integration during the development of HPV-positive tumors (modified from Woodman et al. 2007; Cornet et al. 2015). HPV is thought to access…
Fig. 1 Motor and sensory direct cortical stimulation data. Rendering of left and right hemisphere positive stimulation sites eliciting movement (green) and dysesthesias (yellow) within the precentral and postcentral gyri, respectively….
Fig. 1 Age-standardized incidence rates of malignant brain tumors (males and females combined) per 100,000 persons in 2012 by country (GLOBOCAN) Fig. 2 Age-standardized incidence rates of malignant brain tumor per 100,000…
