21. Gronych J, Korshunov A, Bageritz J, Milde T, Jugold M, Hambardzumyan D, Remke M, Hartmann C, Witt H, Jones DT, Witt O, Heiland S, Bendszus M, Holland EC, Pfister…

The goals of palliative care include: • Provides relief from pain and other distressing symptoms • Affirms life and regards dying as a normal process • Intends neither to hasten…

Class^ Median overall survival (months) 2-year survival (%) 1 58 76 2 37 68 3* 18 35 4* 11 15 5* 9 6 6* 4.5 4 Legend ^Class defined by…

Trial Patients (% GBM) Treatment Med. survival (months) P value BTSG 66-01 [4] 96 (85 %) No radiotherapy 3.5 <0.05 WBRT < 5000 cGy 7.7 WBRT ≥ 5000 cGy 8.4 BTSG 69-01 [3] 222 (90 %) No radiotherapy…

Trial Vaccine Type Phase Experimental design N PFS (mo) OS (mo) NCT00612001 [32]  DC I Autologous DC + selected glioma antigens 6 9.6 18.1 NCT00846456 [59]  DC I/II Autologous DC transfected with…

Fig. 1 Schematic representing select targeted therapies for which clinical trial results are available in high-grade gliomas. Edited with permission from Lee et al. “current and future directions for Phase II…

Study (reference) Number of patients Treatment arms PFS (months) OS (months) Comments EORTC/NCI [1] 573 RT/TMZ versus RT 6.9 versus 5.0 15 versus 12 RT/TMZ superior to RT alone RTOG…

Fig. 1 A schematic overview on the current molecularly based subgrouping. In addition to the standard treatments, radiotherapy (RT), temozolomide (TMZ), procarbazine, lomustine and vincristine (PCV) or radiochemotherapy, there are trials…

Study Design No. of Patients Radiation Chemotherapy Median follow up PFS OS Karim et al. [18] Prospective 379 45 Gy in 5 weeks None 74 months 47 % 58 % 59.4 Gy in 6.6 weeks   50 % 59 %…