Acute Myeloid Leukemia: Conventional Cytogenetics, FISH, and Moleculocentric Methodologies Jennifer J.D. Morrissette, PhD a, Adam Bagg, MD b,*adambagg@mail.med.upenn.edu, a Department of Pathology and Laboratory Medicine, University of Pennsylvania, 201 John…

Table 3 International prognostic scoring system Myelodysplastic Syndromes Olatoyosi Odenike, MD a,b, John Anastasi, MD b,c, Michelle M. Le Beau, PhD a,b,*mlebeau@bsd.uchicago.edu, a Department of Medicine, Section of Hematology/Oncology, University…

Multiple Myeloma: Current Perspectives Marilyn L. Slovak, PhDmarilyn.l.slovak@questdiagnostics.com, Quest Diagnostics Nichols Institute, 14225 Newbrook Drive, Chantilly, VA 20151, USA Keywords • Multiple myeloma • Cytogenetics • Fluorescence in situ hybridization…

Diagnostic Implications of Excessive Homozygosity Detected by SNP-Based Microarrays: Consanguinity, Uniparental Disomy, and Recessive Single-Gene Mutations Hutton M. Kearney, PhD a,*hutton.kearney@msj.org, Joseph B. Kearney, PhD a, Laura K. Conlin, PhD…

Sex Chromosomes and Sex Chromosome Abnormalities Xu Li, MD, PhD xu.li@kp.org, Department of Genetics, Kaiser Permanente, San Jose Medical Center, San Jose, CA 95123, USA Keywords • Sex chromosome •…

Clinical Utility of Single Nucleotide Polymorphism Arrays Stuart Schwartz, PhD, FACMGschwas1@labcorp.com, Cytogenetics Laboratory, Laboratory Corporation of America, 1904 Alexander Drive, Research Triangle Park, NC 27709, USA Keywords • Single nucleotide…

Acute Lymphoblastic Leukemia Christine J. Harrison, PhD, FRCPathchristine.harrison@newcastle.ac.uk, Leukaemia Research Cytogenetics Group, Northern Institute for Cancer Research, Newcastle University, Level 5 Sir James Spence Institute, Royal Victoria Infirmary, Newcastle-upon-Tyne NE1…

Fluorescence In Situ Hybridization Karen D. Tsuchiya, MD a,b,*karen.tsuchiya@seattlechildrens.org, a Department of Laboratory Medicine, University of Washington School of Medicine, 1959 NE Pacific Street, Box 357110, Seattle, WA 98195, USA…

The Evolving Picture of Microdeletion/Microduplication Syndromes in the Age of Microarray Analysis: Variable Expressivity and Genomic Complexity Kristen L. Deak, PhD, Sarah R. Horn, PhD, Catherine W. Rehder, PhD *catherine.rehder@duke.edu,…

Genetics of Chronic Lymphocytic Leukemia Andrea Schnaiter, MD, Daniel Mertens, PhD, Stephan Stilgenbauer, MD *stephan.stilgenbauer@uniklinik-ulm.de, Department of Internal Medicine III, University of Ulm, Albert Einstein Allee 23, 89081 Ulm, Germany…