Fig. 12.1 Prevalence of RBDs according to WFH 2011 survey (www.wfh.org) (closed bars) and EN-RBD (www.rbdd.eu) (open bars) 12.2 Classification of RBDs Most RBDs are expressed phenotypically as a parallel…
History Previous pre-eclampsia Chronic hypertension Renal disease Type 1 or type 2 diabetes Multiple pregnancy Family history of pre-eclampsia Antiphospholipid syndrome Chronic autoimmune disease Increasing maternal age beyond 34 years…
Clinical criteria (one or more) Vascular thrombosis: One or more objectively confirmed episodes of arterial, venous or small vessel thrombosis occurring in any tissue or organ Pregnancy morbidity: One or…
Fig. 7.1 Implantation spectrum Pregnancy itself is a prothrombotic state – characterized by an increase in the levels of pro-coagulant factors, a simultaneous decrease in the levels of anticoagulant proteins,…
Age Greater parity Smoking Cardiovascular disease including: Hypertension Patent foramen ovale Metallic heart valve Renal disease Migraine with aura Heritable thrombophilia Acquired thrombophilia: antiphospholipid syndrome Hyperhomocystinemia Hematological disorders Thrombotic microangiopathies…
Heritable thrombophilia Possible heritable component Acquired risk factors for venous thrombosis Antithrombin deficiency High factor VIII/VWF Increasing age (over 35 in pregnancy) Protein C deficiency High factor IX Pregnancy Protein…
Fig. 2.1 Coagulation mechanism and targets for action of different anticoagulants. UFH unfractionated heparin, AT antithrombin, LMWH low-molecular-weight heparin The amount of activated factor X is further enhanced by the…
© Springer-Verlag London 2015Hannah Cohen and Patrick O’Brien (eds.)Disorders of Thrombosis and Hemostasis in Pregnancy10.1007/978-3-319-15120-5_1 1. Hemostatic Changes in Normal Pregnancy Carolyn M. Millar1 and Michael Laffan1 (1) Centre for Haematology, Faculty of Medicine, Hammersmith Campus, Imperial College,…
Late Effects After Transplantation Bipin N. Savani Minoo Battiwalla INTRODUCTION Allogeneic hematopoietic cell transplantation (HCT) provides curative therapy for a variety of diseases. Over the past several decades, significant advances…
Graft-Versus-Host Disease and Graft-Versus-Tumor Response Joseph Pidala Frederick L. Locke Claudio Anasetti INTRODUCTION Graft-versus-host disease (GVHD) is the most common treatment complication following hematopoietic stem cell transplantation (HSCT) from an…
