Fig. 16.1 68Ga-DOTA-NOC PET/CT images of a patient with a large pNEN of the pancreatic head (a,b,c; SUVmax 40) presenting three additional focal lesions at liver level (a,d,e; SUVmax=7.4). Teaching…
Fig. 3.1 MEN1 gene and missense mutations. (a) Genomic structure of the MEN1 gene. The 10 exons of the gene are shown as boxes that are sized with the indicated…
Fig. 20.1 Distribution of neuroendocrine tumors Except for the undisputed role of surgery in the management of neuroendocrine tumors, the development and registration of the somatostatin analogs (congeners) octreotide and…
Fig. 2.1 Representation of all reported pheochromocytoma/paraganglioma susceptibility genes, specifying the year of publication, with special attention to the genes involved in the hereditary predisposition to the disease (opaque colored…
Fig. 11.1 Krebs cycle gene mutations in pheochromocytoma and paraganglioma and their downstream cellular effects. Mutations in succinate dehydrogenase (SDH) subunit and assembly factor genes, fumarate hydratase (FH), and mitochondrial…
Radionuclide T1/2 (h) Emission Energy deposited (MeV maximum)a Source Ra-223 273.6 4 Alpha 2 Beta 4 Gamma 2 X-ray Alpha 5.6, 6.8, 7.4, (6.6 or 7.50) Beta 0.48, 0.50 Gamma,…
Fig. 19.1 Structural similarities of adrenaline (upper molecule), noradrenaline (middle molecule), and 131I-mIBG (lower molecule) 19.1.2 mIBG: Uptake Mechanism Meta-iodobenzylguanidine moves into cells by the mechanism of noradrenaline reuptake of…
Fig. 5.1 Landscape of genetic variation in high-risk neuroblastoma (Nature Genetics 2013). MYCN amplification, deletion of chromosomes 1p, 3p, and 11q, gain of chromosomes 1q, 2p, and 17q, as well…
© Springer International Publishing Switzerland 2017Karel Pacak and David Taïeb (eds.)Diagnostic and Therapeutic Nuclear Medicine for Neuroendocrine TumorsContemporary Endocrinology10.1007/978-3-319-46038-3_6 6. Molecular Genetics of Gastroenteropancreatic Neuroendocrine Tumours Samuel Backman1 and Peyman Björklund1 (1) Experimental Surgery, Department of Surgical…
Chapter 1Bridging Between Experiments and Equations: A Tutorial on Modeling Excitability David P. McCobb1 and Mary Lou Zeeman2 1Department of Neurobiology and Behavior, Cornell University, Ithaca, NY, USA 2Department of…
