Gene Disease Clinical features Prevalence amongst MODY patients Therapy 1 Hepatocyte nuclear factor-4-alpha 20q MODY 1 Macrosomia, neonatal hypoglycaemia and hyperinsulinaemia; after puberty insulin deficit and diabetes [2] Rare…
Type of device and regulatory classification Novel technology/relevant previous experience Clinical applications and indications Nature of exposure to the products – surface contact, implantation, ingestion Risks inherent in the use…
Fig. 7.1 Types of exercise and their associated glucose changes The greatest acute hypoglycemia risk appears to be for mild-to-moderate-intensity aerobic exercise, especially when performed soon after a meal when…
Fig. 3.1 Active insulin treatment with high insulin doses at diagnosis was associated to higher C-peptide in T1D children (Ludvigsson Thesis 1976) Fig. 3.2 Patients with active insulin treatment which…
© Springer International Publishing Switzerland 2017Andrea Scaramuzza, Carine de Beaufort and Ragnar Hanas (eds.)Research into Childhood-Onset Diabetes10.1007/978-3-319-40242-0_11 11. Risky Behaviours in Teens with Type 1 Diabetes: New Ideas for Research Regarding a Not Too Studied Topic…
Genes related to the lipid homeostasis Fabs The polymorphisms have been studied in several metabolic phenotypes like obesity, metabolic syndrome, hypertriglyceridemia, and insulin sensitivity [6] ELOVL6 Related with insulin resistance…
Fig. 8.1 The healthy plate teaches to organise daily food in a balanced and varied diet. The healthy plate may be organised according to age, sex, level of physical activity…
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© Springer International Publishing Switzerland 2017Andrea Scaramuzza, Carine de Beaufort and Ragnar Hanas (eds.)Research into Childhood-Onset Diabetes10.1007/978-3-319-40242-0_4 4. Adolescent Prevention of Complications M. Loredana Marcovecchio1 and David B. Dunger2 (1) Department of Paediatrics, University of Cambridge, Cambridge, UK (2) Department…
A. Randomized, controlled trials including: Multicenter trial Meta-analysis incorporating quality ratings Compelling nonexperimental evidence (i.e., “insulin to treat diabetes”) B. Well-conducted cohort studies including: Prospective cohort studies or registry Meta-analysis…
