Disorders of LDL Metabolism
Disorders of LDL Metabolism Peter O. Kwiterovich Jr. Peter J. Espenshade Almost 100 years have passed since the classic experiments of Anitschkow and Chalatow (see Ref. 1 for review) who…
ENDOCRINOLOGY
Disorders of Hypertriglyceridemia
Disorders of Hypertriglyceridemia Michael A. Miller In 1959, Drs. Albrink and Mann reported the first association between elevated triglycerides (TG) and cardiovascular disease (CVD) (1). Subsequent case-control and longitudinal studies…
Use of Noninvasive Methods to Diagnose Cardiovascular Disease in Dyslipidemic Patients
Use of Noninvasive Methods to Diagnose Cardiovascular Disease in Dyslipidemic Patients Ilan Gottlieb João A.C. Lima The effect of higher levels of total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C)…
Clinical Trial Evidence for Treatment of Dyslipidemia in the Prevention of Cardiovascular Disease
Clinical Trial Evidence for Treatment of Dyslipidemia in the Prevention of Cardiovascular Disease Thomas A. Pearson Randomized trials with well-defined clinical end points provide the strongest proof that a purported…
Pathophysiology and Vascular Biology of Atherosclerosis
Pathophysiology and Vascular Biology of Atherosclerosis Subroto Chatterjee Over 50 years ago, Dr. Alfred Blalock, a cardiovascular surgeon at the Johns Hopkins Hospital commented, “The heart is an innocent bystander…
Measurement of Lipids, Lipoproteins, and Apolipoproteins
Measurement of Lipids, Lipoproteins, and Apolipoproteins Paul S. Bachorik The concentrations of the plasma lipoproteins strongly predict the development of cardiovascular disease (CVD) and are used to evaluate the dyslipoproteinemias…
Pathogenesis of Atherosclerosis and the Unstable Plaque
Pathogenesis of Atherosclerosis and the Unstable Plaque Frank D. Kolodgie Gaku Nakazawa Aya Nakazawa David R. Fowler Robert Kutys Renu Virmani The earliest descriptions of atherosclerotic lesions focused on morphologies…
Lipid, Apolipoprotein, and Lipoprotein Metabolism: Implications for the Diagnosis and Treatment of Dyslipidemia
Lipid, Apolipoprotein, and Lipoprotein Metabolism: Implications for the Diagnosis and Treatment of Dyslipidemia Peter O. Kwiterovich Jr. Human plasma lipoprotein metabolism is complex. An understanding of normal lipid, apolipoprotein, and…
Water Deprivation Test
Precautions: Severe dehydration (hypotension, tachycardia) may occur in patients with true diabetes insipidus. Weight loss should not be allowed to exceed 5 % of initial body weight and blood pressure should…
Seventy Two Hours Fast for Insulinoma
Symptoms, signs, or both Glucose (mg/dl) Insulin (µU/ml) C-peplide (nmol/L) Proinsulin (pmol/L) β-Hydroxy -butyrate (nmol/liter) Glucose increase after glucagon (mg/dl) Circulating oral hypoglycemic Antibody to insulin Diagnostic Interpretation No < 55…
