Preoperative Functional Evaluation of the Surgical Candidate
Summary of Key Points • Predicted postoperative forced expiratory volume in 1 second (ppoFEV 1 ) has been shown to be inaccurate in predicting actual postoperative FEV 1 in patients…
Positron Emission Tomography Imaging of Lung Cancer
Summary of Key Points • 18 F-2-deoxy- d -glucose (FDG)-positron emission tomography–computed tomography (PET–CT) is routinely used clinically for diagnosis, staging, and radiation treatment planning and may have a role…
Diagnostic Workup for Suspected Lung Cancer Confined to the Chest
Summary of Key Points • In the context of disease confined to the chest, mediastinal staging is crucial for determining the best curative treatment strategy, especially for nonsmall cell lung…
Conventional Imaging of Lung Cancer
Summary of Key Points • Low-dose multidetector computed tomography (CT) screening of active and former heavy smokers has been shown to decrease lung cancer mortality. • The malignant potential of…
Classic Anatomic Pathology and Lung Cancer
Key wordsAnatomic pathology, Cytology sample, Lung cancer classification, Pathologic classification of lung cancer, Pathologic diagnosis, Resected tumor, Small biopsy specimen, Tissue management Summary of Key Points • A clinically…
Management of Small Histologic and Cytologic Specimens in the Molecular Era
Summary of Key Points • Techniques for the optimal triage and preparation of small specimens for diagnosis and ancillary studies are provided. • For optimal results, a standardized protocol and…
Molecular Testing in Lung Cancer
Summary of Key Points • Of key importance is whether a prognostic marker is also a predictive marker for therapeutic benefit. • As predictive biomarkers become integral in the use…
Clinical Presentation and Prognostic Factors in Lung Cancer
Summary of Key Points • Most people with lung cancer are symptomatic at the time of initial presentation; however, between 5% and 15% of people may be asymptomatic. • Alarming…
Humoral and Cellular Immune Dysregulation and Lung Cancer
Summary of Key Points • Humoral and cellular immune dysregulation in the tumor microenvironment contributes to immune evasion, a key hallmark of lung cancer. • Immunosuppressive mechanisms observed in lung…
MicroRNAs as Biomarkers for Lung Cancer
Summary of Key Points • The biologic roles of microRNAs (miRNAs) in lung cancer indicate their correlation with disease status, prognosis, and therapeutic outcome. The discovery of miRNAs has opened…
