Inflammation
Inflammation Sahdeo Prasad Bharat B. Aggarwal INTRODUCTION Extensive research over the last half a century indicates that inflammation plays an important role in cancer. Although acute inflammation can play a…
Oncogenic Viruses
Oncogenic Viruses Christopher B. Buck Lee Ratner PRINCIPLES OF TUMOR VIROLOGY Viral infections are estimated to play a causal role in at least 11% of all new cancer diagnoses worldwide.1…
Molecular Methods in Cancer
Molecular Methods in Cancer Larissa V. Furtado Jay L. Hess Bryan L. Betz APPLICATIONS OF MOLECULAR DIAGNOSTICS IN ONCOLOGY Molecular diagnostics is increasingly impacting a number of areas of cancer…
Hallmarks of Cancer: An Organizing Principle for Cancer Medicine
Hallmarks of Cancer: An Organizing Principle for Cancer Medicine Douglas Hanahan Robert A. Weinberg INTRODUCTION The hallmarks of cancer comprise eight biologic capabilities acquired by incipient cancer cells during the…
The Cancer Genome
The Cancer Genome Yardena Samuels Alberto Bardelli Jared J. Gartner Carlos López-Otin INTRODUCTION There is a broad consensus that cancer is, in essence, a genetic disease, and that accumulation of…
Topoisomerase Interactive Agents
Topoisomerase Interactive Agents Khanh T. Do Shivaani Kummar James H. Doroshow Yves Pommier CLASSIFICATION, BIOCHEMICAL, AND BIOLOGIC FUNCTIONS OF TOPOISOMERASES Nucleic acids (DNA and RNA) being long polymers, topoisomerases fulfill…
Alkylating Agents
Alkylating Agents Kenneth D. Tew PERSPECTIVES Alkylating agents were the first anticancer molecules developed, and they are still used today. After more than 50 years of use, the basic chemistry…
Cutaneous Melanoma
Cutaneous Melanoma Antoni Ribas Craig L. Slingluff Jr. Steven A. Rosenberg INTRODUCTION Melanoma arises from the malignant transformation of the melanocyte, the cell responsible for the production of the pigment…
Genetic Testing in Skin Cancer
Genetic Testing in Skin Cancer Michele Gabree Meredith L. Seidel INTRODUCTION Many hereditary cancer predisposition syndromes are associated with cutaneous findings. Identification of unique dermatologic features provides an opportunity to…
