Alkylating Agents
Alkylating Agents Sheila Shaigany Alkylating agents are highly reactive cytotoxic agents that damage DNA by covalently attaching an alkyl group to guanine molecules present in DNA. This leads directly to…
Severe Cutaneous Adverse Reactions
Severe Cutaneous Adverse Reactions Elisa M. Schunkert Andrew C. Walls Severe cutaneous adverse reactions (SCARs) to drugs include several potentially lifethreatening conditions, such as: SJS/TEN (Stevens-Johnson syndrome/toxic epidermal necrolysis) SJS/TEN-like…
Inflamed Actinic Keratoses
Inflamed Actinic Keratoses Emma H. Weiss Caroline A. Nelson Jonathan S. Leventhal Inflammation of clinical and subclinical actinic keratoses is commonly seen with systemic administration of antimetabolites, such as 5-fluorouracil,…
Hair and Nail Abnormalities
Hair and Nail Abnormalities Jennifer E. Yeh Jennifer T. Huang HAIR CHANGES Hair loss is one of the most common and distressing side effects of cancer treatment and can be…
Radiation Recall
Radiation Recall Stephanie W. Liu Radiation recall is an inflammatory skin reaction that occurs in a previously irradiated field. The recall is triggered by administration of certain pharmacologic agents sometime…
Oral Toxicities
Oral Toxicities Shaiba Sandhu Brittany A. Klein Sook Bin Woo Nathaniel Treister Herve Y. Sroussi Oral mucosal toxicities are a common finding in patients treated with a range of anticancer…
Reactions on the Hands and Feet
Reactions on the Hands and Feet Louise M. Gresham Maxwell B. Sauder Toxicities from anticancer therapies affecting the hands and feet are common and can be divided into three main…
Pigmentary Alterations
Pigmentary Alterations Amina Bougrine Pigmentary alterations caused by anticancer therapies can be seen in any phototype but are more frequent and prolonged in darker phototypes. They are rarely specific to…
Sclerosing Reactions
Sclerosing Reactions Jordan Taylor Said Cecilia Alejandra Larocca Sclerosing reactions are a rare set of cutaneous toxicities that can be caused by chemotherapy, immunotherapy, and radiotherapy—each with a unique presentation….
