Oncohema Key

mTOR Inhibitors Adam Faletsky Shaiba Sandhu Herve Y. Sroussi Lauren M. Guggina The mammalian target of rapamycin (mTOR) is an important factor in cell growth and survival. mTOR is a…

PI3-Kinase Inhibitors Shaiba Sandhu Ashleigh Eberly Puleo Nicole R. LeBoeuf The phosphoinositide 3-kinase (PI3K) pathway is important in cell survival, proliferation, and differentiation1 and is frequently altered in human cancers;…

MEK Inhibitors Michael S. Chang Rebecca I. Hartman The mitogen-activated protein kinase (MAPK) pathway is highly implicated in aberrant signaling leading to carcinogenesis. Primary targets of this signaling cascade include…

BRAF Inhibitors Jordan Talia Christine M. Cornejo Jesse Hirner BRAF is an oncogene encoding the BRAF protein, a component of the MAPK signaling pathway, that regulates cell proliferation, differentiation, survival,…

Epidermal Growth Factor Receptor (EGFR) Inhibitors Timothy M. Dang Daniela Kroshinsky The human epidermal growth factor receptor (HER) family of proteins is normally involved in cell growth and survival.1 HER1,…

Bleomycin Jasmine Rana Bernice Y. Kwong A fermentation product of Streptococcus verticillus, bleomycin exerts a cytotoxic effect on replicating cells by inducing DNA double strand breaks. Bleomycin is administered systemically…

Microtubule Inhibitors Timothy M. Dang Daniela Kroshinsky Microtubule inhibitors are comprised of largely two classes of chemotherapy—taxanes and vinca alkaloids. Taxanes are cytotoxic drugs that promote the polymerization of tubulin…

Anthracyclines Emma H. Weiss Caroline A. Nelson Jonathan S. Leventhal Anthracycline antibiotics are derived from Streptomyces species and are a commonly used cytotoxic treatment for both solid and hematologic malignancies…

Antimetabolites Sheila Shaigany Paul I. Schneiderman Antimetabolites represent a broad class of chemotherapy agents that halt tumor growth by disrupting cellular division in the S phase of the cell cycle….

Topoisomerase Inhibitors Abdulhadi Jfri Christopher Iriarte Victor Huang Topoisomerases are enzymes involved in DNA structure, specifically in breaking and rejoining the phosphodiester backbone of double stranded DNA.1 Topoisomerase I inhibitors…