Morbilliform Reactions
Morbilliform Reactions Connie R. Shi Steven T. Chen Morbilliform eruptions, or exanthematous eruptions, present with numerous erythematous, blanching, nonscaly 3 to 4-mm papules that can coalesce into larger plaques most…
Reactions in Patients with Skin of Color
Reactions in Patients with Skin of Color Oyetewa Oyerinde Michelle S. Lee Jennifer Y. Lin As is the case for the full spectrum of dermatologic disease, manifestations of cutaneous toxicity…
Targeting macrophage migration inhibitory factor to inhibit T cell immunosuppression in the tumor microenvironment and improve cancer outcomes in head and neck squamous cell carcinoma
Highlights • Small molecule MIF inhibitor CPSI-1306 inhibits HNSCC growth in vivo . • CPSI-1306 potently inhibits T cell immunosuppression in the tumor microenvironment. • CPSI-1306 completely abrogates CTLA4, TIGIT…
Multimodal profiling uncovers tertiary lymphoid structures as a critical determinant of immunotherapy response and prognosis in nasopharyngeal carcinoma
Highlights • The immune TME in NPC is unsupervisedly dissected into “Immune Inflamed” and “Immune Deficient” subtypes. • Tertiary lymphoid structures (TLS) serve as better prognostic indicators than individual immune…
Deciphering molecular relapse and intra-tumor heterogeneity in non-metastatic resectable head and neck squamous cell carcinoma using circulating tumor DNA
Highlights • ctDNA provided complementary information on actionable mutations to tissue biopsy. • ctDNA provided a comprehensive view of mutational landscape dynamics over time. • ctDNA-based molecular relapse detection has…
Prophylactic gastrostomy tube during chemoradiation for head and neck cancer decreases weight loss but increases rate of tube use beyond six months
Highlights • Omitting prophylactic PEG and younger age associated with increased weight loss. • Higher risk of feeding tube duration with prophylactic PEG and older patients. • Prophylactic PEG did…
The 10 %-rule debate: A fresh perspective on sentinel lymph node biopsy in OSCC
We wish to address the article entitled “Evaluation of the 10 %-rule in sentinel lymph node biopsy for clinically node-negative oral squamous cell carcinoma” by Tellman et al. . While the…
Predictors of recurrence and survival after salivary gland cancer surgery: A multicenter, retrospective study in northern Japan
Highlights • Lymph node metastasis with extranodal extension was the most important prognostic factor. • Postoperative radiotherapy was associated with a lower risk of recurrence and a good prognosis. •…
Induction chemotherapy for locally advanced nasopharyngeal carcinoma: Efficacy and safety of the TPC regimen compared to GP and TPF
Highlights • This study is the first to explore the efficacy and safety of the docetaxel, cisplatin, and capecitabine (TPC) regimen compared to GP and TPF. • Our findings indicate…
Evaluation of the 10 %-rule in sentinel lymph node biopsy for clinically node-negative oral squamous cell carcinoma
Highlights • The 10%-rule effectively identified metastatic sentinel nodes intraoperatively. • Applying the 10%-rule per neck side must be considered. • Raising the threshold is not advised, as this leads…
