Maturity-Onset Diabetes of the Young
Maturity-Onset Diabetes of the Young Andrew T. Hattersley The early clinical descriptions recognized that maturity-onset diabetes of the young (MODY) was a monogenic form of diabetes with a single gene…
β-Cell Dysfunction in Type 2 Diabetes Mellitus
β-Cell Dysfunction in Type 2 Diabetes Mellitus Jack L. Leahy Type 2 diabetes mellitus is a worldwide health crisis; the World Health Organization predicts an incidence of 300 million by…
Insulin Resistance and Its Role in the Pathogenesis of Type 2 Diabetes
Insulin Resistance and Its Role in the Pathogenesis of Type 2 Diabetes Meredith Hawkins Luciano Rossetti The term insulin resistance generally refers to resistance to the metabolic effects of insulin,…
Type 1 Diabetes Mellitus
Type 1 Diabetes Mellitus George S. Eisenbarth FORMS OF TYPE 1 DIABETES During the past two decades, an accumulating body of information has led to the recognition that the predominant…
Genetics of Type 2 Diabetes
Genetics of Type 2 Diabetes Alessandro Doria Type 2 diabetes, or non-insulin-dependent diabetes (NIDDM), is one of the most common metabolic disorders affecting humans. Approximately 14 million Americans have been…
Genetics of Type 1 Diabetes
Genetics of Type 1 Diabetes Helena Reijonen Patrick Concannon It has long been recognized that certain forms of diabetes cluster within families. In families with type 1 diabetes, the risk…
Epidemiology of Diabetes Mellitus
Epidemiology of Diabetes Mellitus James H. Warram Andrzej S. Krolewski In this chapter, we will review the descriptive epidemiology of type 1 and type 2 diabetes mellitus and discuss its…
Definition, Diagnosis, and Classification of Diabetes Mellitus and Glucose Homeostasis
Definition, Diagnosis, and Classification of Diabetes Mellitus and Glucose Homeostasis Peter H. Bennett William C. Knowler Diabetes mellitus is a heterogeneous group of metabolic disorders characterized by chronic hyperglycemia. Some…
Rodent Models for the Study of Diabetes
Rodent Models for the Study of Diabetes Clayton E. Mathews Edward H. Leiter Patients with diabetes share the clinical symptom of hyperglycemia accompanied by either insufficient circulating insulin or inadequate…
Alterations in Protein Metabolism in Diabetes Mellitus
Alterations in Protein Metabolism in Diabetes Mellitus Craig S. Stump Sreekumaran Nair HISTORICAL PERSPECTIVE Before insulin treatment became readily available, stunted growth, cachexia, and muscle wasting were well recognized in…
