Chapter Outline INTRODUCTION BILIRUBIN METABOLISM Bilirubin Production and Transport Hepatic Uptake of Bilirubin Bilirubin Conjugation Bilirubin Excretion Enterohepatic Circulation of Bilirubin DIAGNOSIS OF HYPERBILIRUBINEMIA Total Serum Bilirubin Measurements Transcutaneous Bilirubinometry…
Chapter Outline DEFINITIONS HISTORY FOLATE Chemistry of Folates Folate Sources, Requirements, and Stores Physiology of Folates Biochemistry of Folates COBALAMIN (VITAMIN B 12 ) Chemistry of Cobalamins Cobalamin Sources, Requirements,…
Chapter Outline INTRODUCTION DEFINITION OF ANEMIA CLASSIFICATION OF ANEMIAS EVALUATION OF THE ANEMIC PATIENT Initial Encounter Selection of Appropriate Laboratory Tests Automated Cell Counting The Blood Film Introduction In this…
Chapter Outline HISTORY AND OVERVIEW CONDITIONING REGIMENS SOURCES OF STEM CELLS Allogeneic Stem Cell Transplantation Autologous Stem Cell Transplantation PERITRANSPLANT SUPPORTIVE CARE Transfusion Support Nutrition Support Infection Prophylaxis and Treatment…
Chapter Outline HISTORY PHYLOGENY MARROW ANATOMY HEMATOPOIETIC CELLS Stem Cells Progenitor Cells Precursors and Mature Cells THE HEMATOPOIETIC GROWTH FACTORS The Lymphohematopoietic Cytokines The Receptor Tyrosine Kinase Ligands The Interleukin…
Chapter Outline APLASTIC ANEMIA Epidemiology Causal Factors Pathophysiology Clinical Evaluation Management and Outcome PURE RED CELL APLASIA Primary Acquired Pure Red Cell Aplasia Secondary Acquired Pure Red Cell Aplasia Acquired…
Chapter Outline HISTORICAL ASPECTS THE Rh BLOOD GROUP SYSTEM Biochemistry and Molecular Genetics RhD ALLOIMMUNIZATION Maternal Rh Sensitization The Nature of Rh Sensitization Pathogenesis of Rh Hemolytic Disease SEVERITY OF…
Chapter Outline ONTOGENY OF THE HUMAN HEMOSTATIC SYSTEM Coagulation Factors Natural Inhibitors of Coagulation Vitamin K–Dependent Factors The Fetal and Neonatal Fibrinolytic System D-Dimers von Willebrand Factor Platelets Blood Vessel…
Chapter Outline INTRODUCTION THE NEONATAL ERYTHROCYTE NORMAL HEMATOLOGIC VALUES NEONATAL ANEMIA HEMORRHAGE IN THE FETUS AND NEWBORN Prenatal Hemorrhage Intrapartum Hemorrhage Postpartum Hemorrhage Clinical Manifestations of Fetal and Neonatal Hemorrhage…
Chapter Outline Examination of blood films 62 Red cell morphology 62 Abnormal erythropoiesis 63 Anisocytosis (ανισοζ, unequal) and poikilocytosis (ποικιλοζ, varied) 63 Macrocytes 65 Microcytes 65 Basophilic stippling 66 Inadequate…
