Locally Advanced Squamous Carcinoma of the Head and Neck David M. Brizel and David J. Adelstein Approximately 50,000 patients are diagnosed annually with squamous cell head and neck cancer (HNC)…
Hyperthermia as a Treatment Modality Mark W. Dewhirst, Paul Stauffer, Zeljko Vujaskovic, Chelsea D. Landon, and Leonard R. Prosnitz The rationale for combining hyperthermia (HT) with radiation (RT) rests on…
Altered Fractionation Schedules Anesa Ahamad This chapter discusses radiotherapy fractionation schedules that are different from the conventional fractionation in the United States of 1.8- to 2-Gy doses given once daily,…
Proton Therapy Nancy Price Mendenhall and Zuofeng Li The burgeoning interest in proton therapy is related to its potential to improve the therapeutic ratio for many malignancies treated with radiation….
Carbon Ions Pascal Pommier, Stephanie E. Combs, and Tadashi Kamada PRESENT STATUS AND PERSPECTIVE FOR CARBON IONS Carbon ion therapy is an innovative radiotherapy modality that is mostly dedicated to…
Radiation Oncology in the Developing World Timothy P. Hanna One of the greatest challenges facing the international radiation oncology community and all other domains of cancer control is the burden…
Photodynamic Therapy Harry Quon, Charles B. Simone, II, Keith A. Cengel, Jarod C. Finlay, Timothy C. Zhu, and Theresa M. Busch The first report of cytotoxicity (in paramecium) observed by…
Chemical Modifiers of Radiation Response David S. Yoo and David M. Brizel Chemical agents have been administered in conjunction with radiotherapy (RT) for both the enhancement of antitumor therapeutic efficacy…
Stereotactic Radiosurgery and Radiotherapy John C. Flickinger and Ajay Niranjan Stereotactic radiosurgery and radiotherapy are techniques to administer precisely directed, high-dose irradiation that tightly conforms to an intracranial target to…
Methodology of Clinical Trials Yaacov Richard Lawrence, James J. Dignam, and Maria Werner-Wasik In this chapter, we discuss the design, conduct, and analysis of oncology clinical trials, pointing out particular…
