Radiotherapy and Regional Nodes
LRR (10 years) Any first recurrence (10 years) Breast cancer mortality (20 years) No RT RT Abs No RT RT Abs No RT RT Abs N = 1314, 1–3+ ALN 20.3 3.8 16.5 45.7…
New Treatments for Metastatic Breast Cancer
Hormone receptor-positive/HER2-negative HER2-positive Triple-negative CDK inhibitors Palbociclib with bazedoxifene in HR-positive breast cancer NCT02448771 CDK4/CDK6 inhibitor, ribociclib (LEE011), in combination with trastuzumab or T-DM1 for HER2-positive advanced/MBC NCT02657343 Palbociclib…
New Thoughts on Atypias of the Breast: Flat Epithelial Atypia, Atypical Ductal Hyperplasia, and Lobular Neoplasia
Fig. 8.1 (a) Flat epithelial atypia (FEA ) (b) Atypical ductal hyperplasia (ADH ) The immediate question a clinician faces when a patient is diagnosed with pure FEA on core…
Genetic Risk Prediction in Breast Cancer
Gene Mammographya RRM RRSO Colonoscopy RR proctocolectomy Pancreatic screening RR gastrectomy Tung NCCN Tung NCCN Tung NCCN Tung NCCN Tung NCCN Tung NCCN Tung NCCN ATM Annually starting at age…
Breast Cancer Treatment in Young Women
© Springer International Publishing AG 2018Marissa Howard-McNatt (ed.)Changing Paradigms in the Management of Breast Cancer https://doi.org/10.1007/978-3-319-60336-0_14 14. Breast Cancer Treatment in Young Women Susan K. Boolbol1 and Sarah Cate1 (1) Mount Sinai Beth Israel Hospital, 10 Union…
Breast Cancer Treatment in Elderly Patients
Age (years) White female (years) Black female (years) Hispanic female (years) 60 24.5 23 26.3 65 20.3 19.3 22.0 70 16.4 15.8 18.0 75 12.8 9.6 14.0 80 9.6 7.1…
Triple-Negative Breast Cancer
Agent Target Stage Phase NCI number Glembatumumab vedotin gpNMB Metastatic I NCT01997333 Panitumumab + chemotherapy EGFR Neoadjuvant II NCT02593175 Selumetinib MEK Neoadjuvant II NCT02685657 Veliparib + lapatinib PARP, EGFR/Her-2 Metastatic…
New Techniques in Radiation Oncology
and Doris R. Brown1 (1) Department of Radiation Oncology, Wake Forest Baptist Health, Medical Center Boulevard, Winston-Salem, NC 27157, USA Doris R. Brown Email: drbrown@wakehealth.edu KeywordsBreast cancerRadiotherapyRegional nodal irradiationPostmastectomy radiotherapyInternal mammary nodal irradiationNeoadjuvant…
Contralateral Prophylactic Mastectomy: Current Perspectives
Study Year published Study period Percentage increase in CPM of all patients over the study period Percentage increase in CPM of all mastectomy patients over the study period Data source…
Management of the Axilla in Breast Cancer
© Springer International Publishing AG 2018Marissa Howard-McNatt (ed.)Changing Paradigms in the Management of Breast Cancer https://doi.org/10.1007/978-3-319-60336-0_4 4. Management of the Axilla in Breast Cancer Toan T. Nguyen1 and Judy C. Boughey1 (1) Department of Surgery, Mayo Clinic, 200…
