Tumor FN-Risk (%) Regimen Breast cancer >20 AC docetaxel, doxorubicin/docetaxel, doxorubicin/paclitaxel, TAC 10–20 AC, EC, docetaxel, FE120C (q4 weeks), CEF <10 CMF Colon cancer 10–20 5-FU/folinic acid FOLFIRI (5-FU/folinic acid/irinotecan)…
Fig. 10.1 Diagnostic procedures and treatment of neutropenic patients with fever and suspected or proven lung infiltrates. CT computed tomography, BAL bronchoalveolar lavage. Dotted lines indicate exceptions from recommended procedure…
Patient-related factors Advanced age (≥65 years) increases risk [26, 28, 108] Performance status ECOG ≥2 increases risk [66, 109] Nutritional status Low serum albumin <35 g/l is associated with increased…
Hypotension (defined as systolic blood pressure <90 mmHg or the need for pressor support to maintain blood pressure) Respiratory failure (defined as arterial oxygen pressure less than 60 mmHg while…
Early onset <28 days Management GI mucositis Chemotherapy/irradiation complicated by OVS or CoNS bacteraemia Pain killers (morphine) and antibiotics Oesophagitis Chemotherapy Antacids Herpes simplex Antiviral prophylaxis Candida spp. Antifungal…
Fig. 15.1 Targets of systemic antifungal agents Clinical outcomes in susceptible isolates are best predicted by the peak serum level to MIC ratio. Serum drug levels are infrequently measured and…
Risk factor for infection Risk category Low High 1. Pretransplant General condition including organ function Performance status Good Poor Renal failure No Yes Diabetes mellitus No Yes Iron stores…
Microorganism Management Coagulase-negative staphylococci Catheter can be removed or retained If removed, systemic antibiotics should be administered for 5–7 days If catheter is retained, treat with a systemic antibiotic and…
Fig. 1.1 Nature of febrile episodes in neutropenic patients 1.4 Microbiologically Documented Infections Microbiologically documented infections also account for 25–30 % of febrile episodes in neutropenic patients (Fig. 1.1). The…
Granulocyte count <500/μl or <1,000/μl with predicted decline to ≤500/μl Single oral temperature of >38.3 °C or ≥38.0 °C × 2 within 12 h or ≥38.0 °C over ≥1 h No obvious…
