Chronic Myelogeneous Leukemia
with indication of high risk by a score >87 and low risk by a score ≤87. Indirectly, the analysis proved that advanced age did not represent an adverse prognostic factor…
Diffuse Large B-Cell Non-Hodgkin’s Lymphoma (DLBCL- NHL)
(a) Diffuse large B-cell lymphoma (DLBCL), NOS T-cell/histiocyte rich large B-cell lymphoma (T/HRBCL) EBV + DLBCL of the “elderly” (b) DLBCL with a predominant extranodal location Primary mediastinal (thymic) large B cell…
Multiple Myeloma
Adverse event Novel agent Action Dose-reductions Neutropenia Lenalidomide, Bortezomib G-CSF until neutrophil recovery in case of uncomplicated grade 4 or grade 2–3 complicated by fever or infection. 25–50 % drug…
Indolent Lymphomas in Older Patients
Small lymphocytic lymphoma/ chronic lymphocytic leukemia B-cell prolymphocytic leukemia Splenic marginal zone lymphoma Hairy cell leukemia Splenic B–cell lymphoma/leukemia unclassifiable a Splenic red pulp small B–cell lymphoma a Hairy cell…
Chronic Lymphocytic Leukemia (CLL)
Fig. 7.1 Age-distribution among patients with newly diagnosed CLL Biology and Aging The etiology of CLL is unknown and its pathogenesis is not fully understood [2]. The reason why CLL…
Diagnostic Radiology in Hematological Patients with Febrile Neutropenia
Fig. 7.1 Contract-enhanced CT demonstrates vessel erosion in a consolidating infiltrate of the left lung. An apposition thrombus can be depicted in the pulmonary artery of the left lower lobe…
Antibacterial Agents
Dosing regimen Duration of infusion (h) MIC (μg/mL) Probability of patients achieving a target T > MIC of 30 % 35 % 40 % 45 % 500 mg every 8…
Central Nervous System Infections
Fig. 13.1 Algorithm to diagnose and to treat empirically/preemptively CNS infections in hematology patients Lumbar puncture and cerebrospinal fluid (CSF) analysis should follow the algorithm in Fig. 13.1 and are…
Myeloid Growth Factors
Tumor FN-Risk (%) Regimen Breast cancer >20 AC docetaxel, doxorubicin/docetaxel, doxorubicin/paclitaxel, TAC 10–20 AC, EC, docetaxel, FE120C (q4 weeks), CEF <10 CMF Colon cancer 10–20 5-FU/folinic acid FOLFIRI (5-FU/folinic acid/irinotecan)…
Pulmonary Complications
Fig. 10.1 Diagnostic procedures and treatment of neutropenic patients with fever and suspected or proven lung infiltrates. CT computed tomography, BAL bronchoalveolar lavage. Dotted lines indicate exceptions from recommended procedure…
