© Springer Science+Business Media New York 2016Ellen F. Manzullo, Carmen Esther Gonzalez, Carmen P. Escalante and Sai-Ching J. Yeung (eds.)Oncologic EmergenciesMD Anderson Cancer Care Series10.1007/978-1-4939-3188-0_7 7. Rheumatologic/Orthopedic Emergencies Huifang Lu1 and Maria E. Suarez-Almazor1 (1) Department of General Internal Medicine,…
Fig. 13.1 Adult-type fibrosarcoma. Fibrosarcoma has evolved from among the most common diagnoses among soft tissue sarcomas to a diagnosis of rigorous exclusion. The morphology depicted, that of a “herringbone”…
Genetic mutation Mutation type Melanoma subtypes affected Melanocytic nevus subtypes affected Type of test KIT Point mutation, amplification Acral (~15 %), Mucosal (~15 %), CSD skin (~10–15 %) Uncommon/rare IHC…
Fig. 12.1 Age-standardized colorectal cancer incidence rates by World Health Organization region and sex for 2008 [4] Mortality rates in the United States have declined since the mid-1980s, due to…
Gene Alteration Frequency (%) Histology Smoking history frequent patterns EGFR Mutation 10–35 Adenocarcinoma, few adenosquamous carcinoma Frequent in never smokers KRAS Mutation 15–25 Mostly in adenocarcinomas, frequently mucinous morphology Former/current…
Example clinical reporting—MGMT Negative result RESULT: Gene Methylation NOT detected Positive result RESULT: Gene Methylation DETECTED Methylation of the MGMT (0 (6)–methylguanine–DNA methyltransferase) gene was detected using methylation specific PCR…
. b) The centromere (cen) is designated 10: p10 is the portion of the centromeric band that faces the short arm; q10 is the portion of the centromeric band…
and John M. Quillin2 (1) Massey Cancer Center, Virginia Commonwealth University Health System, 1101 East Marshall Street, Richmond, VA 23298-0033, USA (2) Department of Human and Molecular Genetics, Virginia Commonwealth University Health System,…
Assay Gene/fusion transcript Gene function Test methodology/specimen Test interpretation Clinical utility IGH-BCL2 Fusion of IGH-BCL2 t(14;18). Translocation of IGH (14q) promoter leads to aberrant overexpression of BCL2 which is anti-apoptotic…
Fig. 9.1 ESR1 (ER) positive by immunohistochemistry Fig. 9.2 ESR1 (ER) negative by immunohistochemistry The IHC results can be reported either as percentage of positive cells or by using one…
