Hemoglobinopathies in Pregnancy
17. Rahimy MC, Gangbo A, Adjou R, Deguenon C, Goussanou S, Alihonou E. Effect of active prenatal management on pregnancy outcome in sickle cell disease in an African setting. Blood….
Thrombotic Microangiopathies in Pregnancy
Primary features Pathophysiology Complications Treatment DIC Abnormal coagulation (increased PT, APTT, reduced fibrinogen and platelets) Underlying precipitant, e.g. placental abruption, sepsis Excessive bleeding or thrombosis Treat the underlying cause…
Thrombocytopenia in Pregnancy: Fetal and Neonatal Alloimmune Thrombocytopenia
Author and year HPA-1a (%) HPA-1b (%) HPA-3a (%) HPA-5a (%) HPA-5b (%) HPA-15 (%) HPA-1a & HPA-5b (%) Other (%) Reznikoff-Etievant (1988) [23] 90 Mueller-Eckhardt et al. (1989) [24]…
Thrombocytopenia in Pregnancy: Gestational Thrombocytopenia and Immune Thrombocytopenic Purpura
Variable GT ITP Gestational age at diagnosis (weeks) 32.8 ± 7.6 20.1 ± 11.1 Gestational age when platelet count counts at nadir (weeks) 35.7 ± 5.5 27.0 ± 11.2 Platelet count at diagnosis (×109/L) 71.3 ± 19.2 40.0 ± 25.5 Platelet count…
Acquired Bleeding Disorders in Pregnancy: Obstetric Hemorrhage
Maternal age over 40 years Multiparity Previous Cesarean section Uterine scarring (previous myomectomy, uterine curettage) Previous spontaneous or induced miscarriage Cigarette smoking and use of drugs such as cocaine Multiple…
Inherited Bleeding Disorders in Pregnancy: Platelet Defects
Severe phenotype platelet function disorders Severe Glanzmann thrombasthenia Severe Bernard-Soulier syndrome Non-severe phenotype disorders Defects in platelet aggregation or adhesion Rare Glanzmann thrombasthenia variants (type II) Rare Bernard-Soulier syndrome variants…
Inherited Bleeding Disorders in Pregnancy: Rare Coagulation Factor Defects
Fig. 12.1 Prevalence of RBDs according to WFH 2011 survey (www.wfh.org) (closed bars) and EN-RBD (www.rbdd.eu) (open bars) 12.2 Classification of RBDs Most RBDs are expressed phenotypically as a parallel…
Pre-eclampsia: The Role of Hemostasis in Its Pathophysiology and Potential Future Therapeutic Options
History Previous pre-eclampsia Chronic hypertension Renal disease Type 1 or type 2 diabetes Multiple pregnancy Family history of pre-eclampsia Antiphospholipid syndrome Chronic autoimmune disease Increasing maternal age beyond 34 years…
Pregnancy Morbidity Associated with Thrombophilias: Late Placenta-Mediated Obstetric Complications
Clinical criteria (one or more) Vascular thrombosis: One or more objectively confirmed episodes of arterial, venous or small vessel thrombosis occurring in any tissue or organ Pregnancy morbidity: One or…
Pregnancy Morbidity Associated with Thrombophilias: Recurrent Miscarriage
Fig. 7.1 Implantation spectrum Pregnancy itself is a prothrombotic state – characterized by an increase in the levels of pro-coagulant factors, a simultaneous decrease in the levels of anticoagulant proteins,…
