The Radiologist’s Approach to CUP
Fig. 6.1 A 43-year-old male patient with multiple endocrine neoplasia syndrome (MEN) type 1. On contrast-enhanced MRI a singular mass in the pancreatic head was observed suspicious for a neuroendocrine…
Novel Diagnostic and Therapeutic Strategies in the Management of Patients with Cancers of Unknown Primary Site
History and physical examination Laboratory tests: CBC, CMP, LDH, urine analysis, PSA in men Computerized tomographic (CT) scans of the chest, abdomen, pelvis Positron emission tomography (PET) scan in selected…
Future Directions
© Springer International Publishing Switzerland 2016Alwin Krämer and Harald Löffler (eds.)Cancer of Unknown Primary10.1007/978-3-319-22581-4_12 12. Future Directions Alwin Krämer1 and Harald Löffler1 (1) Clinical Cooperation Unit Molecular Hematology/Oncology, German Cancer Research Center (DKFZ) and University of Heidelberg,…
Biologic Features of CUP
Fig. 3.1 Hypothetical explanations why there is no primary lesion detectable in CUP. See text for details (Figure adapted from Löffler et al. [4]) The primary tumor is present, but…
Treatment of Disseminated CUP
Resectable disease(“oligometastatic”) Involvement of one lymph node area only (e.g., inguinal nodes), solitary lesions, resectable liver metastases Cervical node metastases with squamous or undifferentiated histology Strong resemblance to head and…
Diagnostic Work-up of CUP: An Approach to Current Recommendations and Underlying Evidence
Fig. 5.1 Diagnostic workup of CUP patients. See text for discussion and further details As stated before, exhaustive diagnostics regardless of expected benefit should be avoided in CUP patients. Indeed,…
Introduction
© Springer International Publishing Switzerland 2016Alwin Krämer and Harald Löffler (eds.)Cancer of Unknown Primary10.1007/978-3-319-22581-4_1 1. Introduction Harald Löffler1 and Alwin Krämer1 (1) Clinical Cooperation Unit Molecular Hematology/Oncology, German Cancer Research Center (DKFZ) and University of Heidelberg, Heidelberg,…
Nanotheranostics
Fig. 1 a Time-lapse near-IRfluorescence (NIRF) imaged mice bearing HCT-116 tumors after intravenous injections of IR-780 micelles. b NIRfluorescence intensities and contrast index (CI) values were quantified at the indicated time…
of DCIS and Progression to Invasive Disease
Fig. 1 The stages of breast cancer. Within the normal mammary duct and TDLU, an inner layer of luminal epithelial cells and a basal layer of myoepithelial cells are surrounded by…
Clinical Role of Genetic Profiling in Breast Cancer
Fig. 1 a The final gene list (16 cancer-related and five reference genes) and summary score (recurrence score) algorithm for this assay were developed by analyzing the results of three independent…
