Fig. 1 Schematic illustration of commonly observed numerical and structural chromosome alterations identified in solid tumors, and the methodologies capable of their detection. Detection of an alteration, however, is not necessarily…
Fig. 1 Karyotype aberrations. Doubling the karyotype results in polyploidy, whereas loss or gain of one entire chromosome results in whole chromosome aneuploidy. Unbalanced structural rearrangements such as gain or loss…
Fig. 1 Summary of the major mechanisms causing CIN in human cancer cells. The major defects leading to chromosome missegregation in human cancer cells are a premature loss of sister chromatid…
Fig. 1 a HDAC2 and TXNL1 immunohistochemical detection in colorectal cancer specimens based on a tissue microarray. Image examples are given at 800-fold magnification. b Tissue-microarray-based immunohistochemical evaluation of HDAC2 and…
Fig. 1 Schematic overview of various genes targeted to provoke CIN in vivo 3 In Vivo Consequences of CIN In the last two decades, a large number of mouse models for…
Fig. 7.1 Frequencies of the CUP syndrome in Germany (The data was made available from the Robert Koch Institute (see [3]) and adapted from [2]). (a) Absolute CUP numbers for…
CUP subset Diagnosticsa Pathology Treatment options Solitary metastatic disease Positron emission tomography (PET) Variable Surgery followed by radiotherapy or chemoradiotherapy adjuvant chemotherapy Neoadjuvant chemotherapy + surgery Definitive radiotherapy or chemoradiotherapy…
Metastatic sites Start of follow-up 0 months+ 3 months+ 7 months+ Cases (%) Cancer deaths Median survival Cases (%) Cancer deaths Median survival Cases (%) Cancer deaths Median survival Lymph…
(1) RadioOnkologie und Strahlentherapie, UniversitätsKlinikum Heidelberg, Im Neuenheimer Feld 400, Heidelberg, 69120, Germany David Krug Email: david.krug@med.uni-heidelberg.de 9.1 Curative Treatment Concepts 9.1.1 Axillary Cancer of Unknown Primary 9.1.1.1 Introduction…
Citation Study population Survival data, selected prognostic factors, comments Altman and Cadman (1986) [30] 1539 cases from a single center (USA), 1922–1981 Median OS 5 months. 56 % of cases…
