Development of Glypican-3-Targeted Cancer Immunotherapy
Peptide dose Number of cases RECIST evaluationa Decreased tumor marker PIVKA-II CTL frequencyb 0.3 mg 8 SD 3, PD 5 0/8 (0 %) 7.5 1.0 mg 6 SD 4, PD…
In Vivo Targeting of Dendritic Cells with Artificial Adjuvant Vector Cells (aAVC) as a Novel Cancer Immunotherapy
Fig. 13.1 Invariant natural killer T (iNKT) cell-mediated adjuvant effects on T cells are dependent on the innate immunity. Intravenously administered artificial adjuvant vector cells (aAVCs) are killed by iNKT…
Innate Immune Receptor Signaling and IRF Family of Transcription Factors: Good Deeds and Misdeeds in Oncogenesis
Fig. 7.1 Classification of CLRs by intracellular signaling motifs. Representative CLRs are classified based on their intracellular signaling motifs: ITAM-containing receptors (such as Dectin-1, CLEC2, CLEC9A, and SIGN-R3), adaptor-recruiting receptors…
Development of Immunotherapy for Hepatocellular Carcinoma
Year Author No. of patients Setting for DCs Responses 2002 Ladhams et al. 2 GM-CSF/IL-4 DC + tumor 1/2 inhibition of tumor growth 2003 Iwashita et al. 10 GM-CSF/IL-4 DC + tumor lysate + TNF-α + KLH 1/10…
Prevention and Treatment of Cardiac Dysfunction in Breast Cancer Survivors
History Parameter Action Age/family history Obesity BMI Avoid further gain, gradual loss Diabetes HbA1C/Fasting glucose Initiate diabetic therapy Inactivity Minutes of recreational physical activity/week Encourage 150 min or more recreational…
Quality of Care, Including Survivorship Care Plans
Fig. 17.1 Conceptual framework for receipt of optimal cancer care (Adapted from Shavers and Brown, JNCI 2002 with permission) After the initial treatment decisions are made, and treatments are underway,…
Living with Metastatic Breast Cancer
Physical and medical challenges Managing physical symptoms and side effects (e.g., pain, fatigue) Dealing with constant or changing treatment schedules Accepting stable disease as a desirable outcome of treatment Maintaining…
Special Issues in Older Women with Breast Cancer
Fig. 3.1 Projected cases of all invasive cancers in the United States by age and sex [Reproduced with permission from Smith et al. (2009)] Although breast cancer is associated with…
Symptoms: Fatigue and Cognitive Dysfunction
Fig. 5.1 Model for explaining the influence of cancer and its treatments on common behavioral alterations including fatigue and cognitive dysfunction [Reproduced with permission from Miller et al. (2008)] These…
Symptoms: Menopause, Infertility, and Sexual Health
Reproductive stage (STRAW) Known physiology Behavioral correlates Known predictors of menopause transition or behavioral correlates Reproductive early to late Normal to elevated FSH Menstrual cycles obtain regularity; later AMH drops…
