Depression, Anxiety, and Fatigue Carlos G. Fernandez-Robles, William F. Pirl INTRODUCTION Depression, anxiety, and fatigue are frequent complications of cancer and cancer treatment. Although fatigue can be caused by depression…
Immunomodulatory Drugs and Proteasome Inhibitors Anuj Mahindra, Hamza Mujagic, Bruce A. Chabner The therapeutic options for the treatment of multiple myeloma (MM) have expanded over the past decade with the…
Adduct-Forming Agents: Alkylating Agents and Platinum Analogs Bruce A. Chabner Since the first clinical experiments with nitrogen mustard at Yale in the early 1940s, alkylating agents have played a primary…
Febrile Neutropenia Stephen M. Carpenter, Fabrizio Vianello, Mark C. Poznansky INTRODUCTION Immune-compromised state refers to a change of the host defense systems that confer an increased susceptibility to infection. Neutropenia…
Acute Lymphoblastic Leukemia and Lymphoma James W. Fraser, Janet E. Murphy, Eyal C. Attar INTRODUCTION Acute lymphoblastic leukemia (ALL) is a highly aggressive neoplasm of hematopoietic cells of lymphoid lineage….
Head and Neck Cancer Lori J. Wirth, Paul M. Busse, Daniel Deschler INTRODUCTION Cancers of the head and neck are composed of a spectrum of malignant neoplasms. Most commonly, however,…
Rectal Cancer Theodore S. Hong EPIDEMIOLOGY In 2013 there were approximately 143,000 Americans diagnosed with colon and rectal cancer. Approximately 2/3 will involve the colon and 1/3 the rectum. Epidemiological…
Bladder Cancer Richard J. Lee EPIDEMIOLOGY AND RISK FACTORS More than 350,000 new cases of bladder cancer are diagnosed per year worldwide. In the United States, bladder cancer is the…
Comprehensive End-of-Life Care Jennifer Shin, Jennifer Temel INTRODUCTION Comprehensive end-of-life (EOL) care is an essential component of oncology. While we aim to cure as many patients as possible, many of…
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