Topoisomerase IIα Topoisomerase IIβ Unlinks tangled daughter chromosomes after replication and resolves DNA knots during recombination. Essential for survival of proliferating cells and its levels rise during cell growth. Essential…
Technique Resolution Sensitivity Purification Loading capacity Protein/peptide identification Limitations SELDI-TOF Low Low Not required Low No No peptide identification nLC-MS/MS Medium Low Required Low Yes Limited loading capacity 2DE-MS Low…
Cervical cancer stem cell marker Function of marker Sample % of marker positivity Characteristics of CSC isolated References CK17 p63 CK17 – differentiation marker p63 – TF activated at embryonic…
Fig. 1.1 Giemsa-stained normal metaphase spreads from bone marrow preparations of (a) mouse, showing all acrocentric chromosomes (2n = 40), and (b) rat, showing acrocentric, submetacentric, and metacentric chromosomes (2n = 42) Mammalian species…
Conc. μg/mL 0 25 50 75 100 Compound Viable cells, % GH 100 76 15 0 0 GM 100 65 50 40 40 GL 100 75 56 60 60 GA…
1 Reduction of adverse effects from chemotherapy and radiotherapy, with particular reference to nausea and vomiting 2 Management of pain 3 Reduction of adverse effects due to iatrogenic menopause 4…
Fig. 17.1 (a) Schematic diagram showing folate-targeted nanoparticle (FNP) containing siRNA. (b) Transmission electron microscopy showing that HuR-FNPs are uniform in size and shape and do not show aggregation Fig….
Fig. 14.1 Percentage apoptosis in primary ovarian cancer cells on treatment with metformin and chemotherapeutic agents In this study, we investigated whether metformin could induce apoptosis in ovarian cancer cells….
Primary tumor (T) TX Primary tumor cannot be assessed T0 No evidence of primary tumor Tis Carcinoma in situ T1 Tumor invades lamina propria or muscular layer T1a Tumor invades…
Fig. 10.1 Estimated age-standardized rates (world) per 100,000 incidence and mortality of cancer in more and less developed countries (GLOBOCAN 2012) 10.2 Indian Scenario With an estimated burden of over…
