Chemotherapy: First-Line Strategy
Albuminemia <35 g/L Lymphopenia <1 G/L ADL score <6 IADL score <25 HADS score >14 The number of points is the sum of “yes” A vulnerable patient is defined as…
How to Design Clinical Trials?
© Springer International Publishing Switzerland 2016Gilles Freyer (ed.)Ovarian Cancer in Elderly Patients10.1007/978-3-319-23588-2_8 8. How to Design Clinical Trials? Sandro Pignata1 , Sabrina Chiara Cecere1 and Rosa Tambaro1 (1) Dipartimento Uro-Ginecologico, Istituto Nazionale Tumori “Fondazione G Pascale” – IRCCS, Naples,…
Management of Antiangiogenic Agents
Clinical trial Phase Treatment schema N Median age [range] Responses CR + PR or HR Median PFS Cannistra (2007) [6] II Bev monotherapy 44 59.5 [31–87] 16 % 4.4 months Burger (2007)…
Histopathology of Ovarian Cancers in Elderly Patients
HG serous LG serous Mucinous Endometrioid Clear cell Incidence 70 % <5 % 3 % 10 % 5–10 % Risk factors BRCA1/2 ? ? HNPCC HNPCC+/- Precursor lesions STIC…
Chemotherapy for Recurrent Ovarian Cancer in the Elderly Patients
C-PLD C-P p Febrile neutropenia None 100 94 0.038 Present 0 6 Alopecia None 89 14 <0.001 Partial/complete 11 86 Sensory neuropathy Grade 0–1 90 64 <0.001 Grade 2–3…
Exhaled Volatile Organic Compounds as Noninvasive Markers in Breast Cancer
GC-MS Sensor array Compounds Volatile and semi-volatile compounds Tunable through choice of sensors Accuracy of compound identification Very high No compound identification Detection limit ~ppm v , can be…
Imaging Technologies and Applications in Early Diagnosis and Prognosis for Breast Cancer
Organization Screening recommendations AAFP Every 1–2 years, ages 50–69; counsel women ages 40–49 about potential risks and benefits of mammography and clinical breast examination ACOG Every 1–2 years starting at…
Breast Cancer Proteomics
Fig. 9.1 The histogram shows the rate of increase per year in scientific publications indexed by PubMed, regarding the most frequent types of cancer: breast, lung, prostate, colon, and thyroid…
Breast Cancer Gene Therapy
(1) Pharmaceutical Biotechnology, Faculty of Pharmacy, Anadolu University, Tepebaşı, Eskişehir, Turkey (2) Yunusemre Campus, Anadolu University, Eskişehir, Turkey (3) Anadolu University, Tepebaşı, Eskişehir, Turkey Abstract Breast cancer, one of…
Omics of Hereditary Breast Cancer
Database Curator Publication Gene Expression Omnibus (GEO) National Center for Biotechnology Information (NCBI) [111] Riken Expression Array Database (READ) Riken [112] ArrayTrack U.S. Food and Drug Administration (FDA) [113] ArrayExpress…
