Pharmacokinetic Aspects of Regional Tumor Therapy
PK parameter Dimension Relevance t 1/2zp Time Transfer from blood to deep compartment t 1/2el Time Elimination half-life from the body c max Concentration/volume Peak concentration in blood or tissue…
Chemoembolization of Lung Tumors
Model Lung unilateral embolization with DSM ± carboDDP, rats: study of pulmonary microcirculation by measurement of FITC-labeled erythrocytes N 12 (2 × 6) Objective Pulmonary microcirculation Comparisons 1. unilateral embolization with DSM 2. unilateral…
Radiofrequency Ablation for Treating Malignant Tumors to the Liver
Author Method Patients (n) Tumor size (cm) Overall survival p 1 y (%) 3 y (%) 5 y (%) Vivarelli (2004) [17] Surgery 79 n.a. 83 65 n.a. 0.002 RFA…
Liver Metastases of Other Indications
Concept Resection + intra-arterial chemotherapy vs. resection alone N 51 Access Catheter via A. femoralis in truncus coeliacus Therapy d1: 10 mg/m2 mitoxantrone (over 1 h) d2–4: 170 mg/m2 FA (over 10…
Liver Metastases of Neuroendocrine Tumors and CCC
Concept TACE of advanced liver metastases of neuroendocrine tumors (retrospective analysis) N 26 (10× carcinoid syndrome, 2× midgut tumors, 7× pancreatic tumors, 2× malignant insulinomas, 1× stomach carcinoid, 4× CUP)…
CRC Liver Metastases
Concept Adjuvant HAI after resection of colorectal liver metastases (randomized comparison of HAI + IV vs. IV) N 156 Inclusion criteria R0 resection Therapy 1. (HAI + IV): IV: 325 mg/m2 5FU d1–5 (bolus) + 200…
Diagnostic Imaging of the Esophageal Cancer
Fig. 3.1 Normal CT anatomy of the hypopharynx and cervical esophagus. (a) Contrast-enhanced axial CT image obtained at the level of the hypopharynx. The ossified cricoid cartilage (Cr) is identified…
Pathology of Esophageal Squamous Cell Carcinoma
Fig. 2.1 Classification of the depth of invasion 2.2 Macroscopic Features 2.2.1 Handling of Specimens The proper handling of a specimen by a competent pathologist is the most important step…
Stage Classifications: The UICC/AJCC Classifications and the Japanese Classification
Fig. 5.1 History of TNM Classification of Malignant Tumours, AJCC Cancer Staging Manual and Japanese Classification of Esophageal Cancer, TNS* Tumor Nomenclature and Statistics, CSCAS* Clinical Stage Classification and Applied…
