Molecular Medicine and Personalized Therapy for Breast Cancer Patients
Test IHC Fish Positive for HER2 HER2 3+ (defined as uniform intense membrane staining of >30 % of invasive tumor cells) HER2 amplified (FISH ratio of HER2 to CEP17 of…
Mastectomy for Invasive Breast Cancer
Fig. 14.1 Oblique elliptical incision for simple mastectomy An incision is made through the dermis and the skin is elevated using penetrating skin hooks. A dissection plane is developed in…
Inflammatory Breast Cancer
Fig. 15.1 (a) Punch biopsy of the skin demonstrates small-, medium-, and large-sized lymphovascular tumor emboli and the superficial dermis from a patient with clinical manifestation of IBC. (b) The…
Lobular Neoplasia: Atypical Lobular Hyperplasia and Lobular Carcinoma In Situ
Study, year (Ref.) N No. cancers (%) Mean follow-up (years) Ipsilateral cancer (%) Contralateral cancer (%) Lobular histology (%) Hutter, 1969 [12] 40 15 (33) 4–27 59 41 NR Haagensen,…
The Multidisciplinary Breast Cancer Program: Patient Navigation
Fig. 32.1 The top tasks, knowledge areas, and skills as rated by respondents (Reprinted with permission from Brown et al. [21]. Copyright 2012 by Oncology Nursing Society) A breast cancer…
Adjuvant Biologic Agents for Breast Cancer
Number of patients DFS/RFS HR (95 %CI or p value) OS Cardiotoxicity Comments NSABP B31/N9831 [35] 5,548 0.60 (0.53–0.68) 0.63 (0.54–0.73) 4.1 % The N9831 also included a sequential…
Adjuvant Therapy for Breast Cancer: Hormonal Therapy
Toxicity HR Endometrial cancer 3.28 Pulmonary embolism 2.15 Deep venous thrombosis 1.44 Bone fractures 0.68 In the most recent Oxford Overview Analysis, there was a nonsignificant increase in stroke deaths…
Adjuvant Chemotherapy in Breast Cancer
Regimen Dose Cycle duration No cycles Notes Reference Non-anthracycline containing Oral CMF Cyclophosphamide (100 mg/m2, PO) d1 to 14 Methotrexate (40 mg/m2) d1, 8 5-Fluorouracil (500 mg/m2) d1, 8 q4…
The Initial Consultation: Malignant Disease
Fig. 7.1 (a, b) The Advocate Christ Medical Center’s multidisciplinary oncology breast clinic’s intake form The history of present illness should note the means of how the cancer was initially…
Operative Management of Metastatic Breast Cancer
© Springer Science+Business Media New York 2015Adam I. Riker (ed.)Breast Disease10.1007/978-1-4939-1145-5_16 16. Operative Management of Metastatic Breast Cancer Hannah W. Hazard1 (1) Department of Surgery, Health Sciences Center – South, West Virginia University School of Medicine,…
