Fig. 8.1 Three unique PDX models of early-stage, well-differentiated, androgen-responsive prostate cancer, respectively, all expressing AR and PSA [22, 37] The significant expansion of the number of PDXs for prostate…
© Springer International Publishing AG 2017Robert M. Hoffman (ed.)Patient-Derived Mouse Models of Cancer Molecular and Translational Medicinehttps://doi.org/10.1007/978-3-319-57424-0_21 21. Afterward: The Future of Patient-Derived Models of Cancer Robert M. Hoffman1, 2 (1) AntiCancer, Inc., 7917 Ostrow Street,…
Fig. 20.1 Drug efficacy testing in the PDOX model of HER-2-expressing cervical carcinoma. PDOX nude mice were treated with saline, carboplatin, trastuzumab + lapatinib, trastuzumab + lapatinib + entinostat, or…
Fig. 13.1 Patient sarcomas and melanomas were obtained at surgery, established in nude mice and subsequently implanted orthotopically in nude mice and treated with drugs indicated [26, 27, 30–34, 57]….
© Springer International Publishing AG 2017Robert M. Hoffman (ed.)Patient-Derived Mouse Models of Cancer Molecular and Translational Medicinehttps://doi.org/10.1007/978-3-319-57424-0_2 2. The Revival of Patient-Derived Xenograft Mouse Models of Cancer: Way Back to the Future Robert M. Hoffman1, 2 …
Fig. 10.1 Drug-efficacy testing in the PDOX model. PDOX nude mice were treated with saline, carboplatin, trastuzumab + lapatinib, trastuzumab + lapatinib + entinostat, or entinostat alone. (a) Bar graphs…
The athymic “nude” mouse is possibly the most important tool in cancer research. The nude mouse has enabled the studies of human cancer in the laboratory in vivo. Nude mice…
© Springer International Publishing AG 2017Robert M. Hoffman (ed.)Patient-Derived Mouse Models of Cancer Molecular and Translational Medicinehttps://doi.org/10.1007/978-3-319-57424-0_7 7. The First Patient-Derived Orthotopic Xenograft (PDOX) Mouse Models of Cancer: Cancer of the Colon, Pancreas, Lung,…
© Springer International Publishing AG 2017Robert M. Hoffman (ed.)Patient-Derived Mouse Models of Cancer Molecular and Translational Medicinehttps://doi.org/10.1007/978-3-319-57424-0_6 6. Techniques for Surgical Orthotopic Implantation of Human Tumors to Immunodeficient Mice Robert M. Hoffman1, 2 (1) AntiCancer, Inc.,…
Fig. 7.1 The JAK-STAT signalling pathway. Upon binding to the membrane receptors, cytokines initiate downstream signalling cascades through the JAK-STAT pathway. Cytokine receptor homodimers or heterodimers phosphorylate and activate JAKs,…
