Hospital Medicine


Organ/system

Age-related physiologic change

Consequences of aging, not disease

General

↑ Body fat

Altered drug distribution

↓ Total body water
 
Endocrine

Impaired glucose homeostasis

↑ glucose during stress

↑ ADH, ↓ renin, and ↓ aldosterone

Disrupted volume homeostasis

Respiratory

↓ Lung elasticity and ↑ chest wall stiffness

Increased effort, atelectasis when bed or chair bound

Decreased recoil

↓ Exercise tolerance

Decreased DLCO
 
Decreased cough reflex

Micro-aspiration
 
Ventilation/perfusion mismatch

Increased A-a gradient

Decreased resting P02

Hematologic/immune system

↓ T cell function

↓ Response to pathogens

↑ Autoantibodies
 
Musculoskeletal

↓ Lean body mass, muscle

↓ Strength

↓ Bone density

Osteopenia

Cardiovascular

↑ LVH, arterial stiffness

Impaired orthostatic responses; HFpEF (e.g., diastolic dysfunction)

↓ B-adrenergic responsiveness

↓ baroreceptor sensitivity
 
↓ cardiac output and HR response to stress
 
Hypotensive response to ↑ HR or dehydration

Renal

↓ GFR

Impaired drug excretion

↓ urine concentration/dilution

Delayed response to salt/fluid restriction or overload


Adapted with permission from Fedarko NS, McNabney MK. Biology. In: Durso SC, Sullivan GM, eds. Geriatrics Review Syllabus: A Core Curriculum in Geriatric Medicine, 8th ed. New York, NY: American Geriatrics Society; 2013, and Kasper et al., Harrison’s Principles of Internal Medicine, 16th Edition, McGraw-Hill, adapted with permission of McGraw Hill Education








    7.3 Marked Heterogeneity Among Older Adults


    Descriptions of age-related physiologic declines and co-morbidities give the impression that the older population is clinically homogenous, but this is not true. Older adults experience physiologic aging at very different rates, and even in the same person, different organ systems age at varying rates; and as a result, older adults are more different from one another than are younger patients. Older adults also suffer from age-related chronic conditions such as heart disease, diabetes, and geriatric syndromes such as dementia, frailty, and incontinence, in unpredictable ways. More than 50 % of older adults have more than three chronic conditions, called multi-morbidity [6]. As a result, there is marked clinical heterogeneity and the overriding lesson is that age itself does not predict a person’s state of health or wellness, which may range from resilient to frail.



    • An individualized geriatric assessment is a major step in the management of the older hospitalized adult. It provides the essential framework to deliver personalized, high quality and safe care for this high-risk and diverse group of patients.


    7.4 Assessment of the Hospitalized Older Adult: Key Themes and Common Pitfalls


    Although the hospital is often lifesaving, for an older adult, it also presents serious challenges with potentially devastating consequences. Approximately one-third of patients older than age 70 develop a potentially preventable hospitalization-associated disability despite successful treatment of the acute illness. This often results in impairment of activities of daily living (ADLs) and an inability to continue to live independently [7, 8]. A systematic approach is required to identify and manage these challenges, which include cognitive and functional decline, adverse effects from medications [9], and other components. Several risk-prediction scoring tools are available to identify hospitalized older adults at risk for new-onset disability, adverse medication effects, and other hospital-associated complications. These tools can assist in targeting the high risk patients and inform clinical care [10]. Identification of frailty provides important prognostic information regarding morbidity and mortality [1113].


    7.4.1 Geriatric Assessment in the Hospital


    Geriatric assessment (GA) has evolved to meet diverse clinical needs in a variety of settings. Core GA components involve the identification of medical, physical, functional, social, and psychological issues that then link to a coordinated team-based plan of care. GA focuses on a senior’s unique presentation of acute illness, and plans for the prevention of common adverse events during hospitalization. A recent review reported that hospitalized patients who received GA with a subsequent individualized care plan compared to those without GA were more likely to be alive and in their own homes after a year (and not be institutionalized) and more likely to have maintained their baseline cognitive function [14].



    • A geriatric assessment on admission to hospital identifies the patient’s baseline status, targets common geriatric problems and hazards that would otherwise have been unsuspected or disregarded, expands upon usual medical assessment to reduce hospital-associated risks and improve outcomes, and initiates planning for transition of care (Table 7.2).


      Table 7.2
      Routine assessment for hospitalized older adults
























































































































































      History and physical

      Geriatric area

      Specific geriatric assessment

      Why assess?

      Care preferences

      Advance care planning

      • Review DMPOAHC and/or Living Will (if available)

      • Guides care

      • Assess capability of medical decision making
       

      • Assess goals of care, values, and preferences
       

      Past history

      Healthcare utilization

      • Review ED or hospital admission within 30 days

      • Targets risk and informs transitions

      Vaccination

      • Review pneumococcal and influenza immunization status

      • Hospital is good site for updating vaccinations

      Functional status

      Functional status

      • Assess ADLs, IADLs

      • Targets risk and informs transitions

      • Ask: Have you recently had a decline in your functioning?
       

      • Ask: Do you have help at home? What do they help you with? (e.g., shopping, meals, taking a bath or shower, transportation, managing finances)
       

      Medication review

      Over-and-under treatment

      • Review each medication for indication, dose, and adverse effects

      • Mitigates adverse medication effects and errors

      Adverse effects

      • Review high risk medications (e.g., psychotropics, anticholinergics)

      • Informs transitions

      • Ask: Are there any medications that have been recently started?
       

      Adherence

      • Ask: About how many doses do you miss a week?
       

      • Ask: What do you do to make sure you get your mediations? (e.g., caregiver help, pill boxes)
       

      Social history

      Social support

      • Ask: Where do you live? (e.g., home, assisted living, nursing home).

      • Informs transitions

      • Ask: Who lives with you?

      • Assists with prevention strategies (ETOH withdrawal)

      • Ask: Are you a caregiver for someone else?

      • Informs transition; may need to report

      Alcohol use

      • Ask: How many drinks (alcohol) do you have a week?
       

      • Administer: CAGE
       

      Elder mistreatment

      • Ask: Do you feel safe at home?
       

      Review of systems

      Cognition

      • Ask: Have you had problems with your memory or confusion?

      • Informs hospital course and transition (don’t make diagnosis of dementia in hospital setting)

      Mood

      • Ask: (PHQ-2): Over the past month, have you often had little interest or pleasure in doing things? Have you been bothered by feeling down, depressed, or hopeless?
       

      Incontinence

      • Ask: Do you have trouble holding your urine? Do you wear a pad?
       

      Falls

      • Ask: Have you fallen in the past 6 months?
       

      Nutrition

      • Ask: Have you lost weight in the past 6 months? How much?
       

      Vision/hearing

      • Ask: Do you have problems seeing or hearing?
       

      Skin

      • Ask: Do you have any skin sores or ulcers?
       

      Pain

      • Ask: Are you having pain?
       

      Physical assessment

      General/VS

      • Assess temperature

      • Informs hospital course and transition

      • Check orthostatic BP and heart rate
       

      • Calculate BMI
       

      • Consider frailty assessment
       

      Perform daily skin exam
       

      • Assess for delirium
       

      Cognition

      • Perform Mini-Cog (3-item recall and clock or other cognitive screen
       

      Gait

      • Observe patient getting up and walking
       

      Labs

      Renal function

      • Estimate CrCl (Cockcroft–Gault formula)

      • Mitigates errors in dosing


      Modified with permission from: Pierluissi E, Sotelo M. Hospital Care. In: Durso SC, Sullivan GM, eds. Geriatrics Review Syllabus: A Core Curriculum in Geriatric Medicine, 8th ed. New York, NY: American Geriatrics Society; 2013

    The following is a list of recommended steps, recognizing that there is significant overlap and that the order and timing of each may be modified based on the patient’s acuity and clinical scenario.


    7.4.1.1 Step 1: Assess Capacity for Medical Decision Making


    The patient must have the capacity for medical decision-making in order to fully engage in a discussion about goals, values, and preferences. Since approximately 1/4 of hospitalized elders lack decision-making capacity, all hospitalists must be skilled in assessing decision-making capacity and must routinely determine this capacity in older patients—not just when prompted by a patient’s unusual behavior or denial of a recommended treatment [15]. Importantly, a patient with dementia may still maintain decisional capacity. The assessment of a patient’s medical decisional capacity involves his or her ability to understand the consequences of a decision. Four elements of a decision-making capacity assessment include: (1) communicating a choice, (2) understanding the question asked, (3) appreciating the situation, and (4) demonstrating reasoning. Capacity is determined in relation to a specific question or situation and must be reassessed as the clinical picture changes [16]. Several tools are available to help structure the assessment including the Aid to Capacity Evaluation tool [17]. Specialty consultants, including psychiatrists, may be brought in when there is evidence for depression or psychosis complicating the discussion. Chapters 4 and 6 also provide information on determining decision-making capacity.



    • Assessing a patient’s medical decision-making capacity is within the hospitalist’s scope of practice.


    7.4.1.2 Step 2: Establish Goals, Values, and Preferences


    Establishing the patient’s goals, values, and preferences is a very early step in GA. Specific treatment decisions follow this understanding and it should drive the hospital management plan. Determine if the patient has any advance care planning in place (e.g., durable medical power of attorney for health care, living will, etc.) and follow the patient’s desired wishes as best as possible. A helpful framework in discussion with patients with multi-morbidity includes attention to treatment-related risks, burdens, and benefits, including their anticipated life expectancy, functional impairments, and quality of life [6, 18].

    To develop a plan of care in alignment with patient/family goals, preferences, and values, engage in a discussion following these guidelines. Before beginning the discussion, be as prepared as you can be with the facts of the case and share this information with the patient and family to ensure understanding. Ask open-ended questions and be prepared to listen and respond to the patient’s questions and concerns. Examples of how to start the conversation include: “What would you like to see happen?”, “What would you like to avoid?”, “What fears or worries do you have about your illness or medical care?”, and “What are you hoping for now?”, and “What is important to you?” Specific issues to discuss (in addition to resuscitation orders and code status) may include (as appropriate) ICU care, dialysis, nutritional support, future hospitalizations, and the role of comfort measures. Confirm understanding of the patient’s wishes at the end of discussion.

    With a structured approach and practice, the discussion can be completed within a short time. The benefit to patient, family, consultants, and all involved hospital personnel is invaluable in focusing on the goals of care. In many cases, managing patient and family expectations is a key part of the initial and follow-up discussions.

    At times, these expectations may be overly optimistic, failing to appreciate an extremely poor prognosis. Other times, the expectations may be based on age-related stereotypes that unreasonably deny the opportunity for an elder to recover from their acute illness. For example, a family may misunderstand the clinical picture of delirium and acute onset of urinary incontinence (two common adverse effects in the hospital setting) and come to the conclusion that their loved one suffers from dementia and chronic urinary incontinence. They may then believe that they can no longer care for the patient at home. These inappropriate diagnoses, if unchallenged by the hospital team, impact further care. The family may decide that a transfer to a more supervised setting is in their loved one’s best interests, and the family’s lowered expectations for recovery often solidify cognitive and functional losses.



    • Directly discuss the patient’s goals, values, and preferences . Develop and implement a care plan based on achieving these goals, as best as possible. Strongly consider consulting the palliative care team (discussed in depth in Chap. 6) or the ethics committee if patient and/or family expectations appear to be unrealistic or if there is conflict.


    7.4.1.3 Step 3: Conduct an Effective and Efficient History and Physical


    The traditional history and physical includes past medical history, medication review, social history, review of systems, and physical exam. Within these domains, several assessments should be systematically incorporated to elicit important geriatric issues. For example, in addition to gathering the list of medications, directly ask the patient and/or caregiver to describe the strategies they use to ensure medication adherence and carefully consider whether the medications (or lack thereof) could be contributing to the patient’s acute illness. In addition to usual social history questions, ask the patient about any help they require from others to meet their Activities of Daily Living (ADLs) or Instrumental Activities of Daily Living (IADL) needs, or if they feel safe at home. In the review of systems, ask about vision and hearing problems or weight loss in the prior 6 months. For the physical examination, checks of orthostatic blood pressure and gait are very informative. Utilize the hospital team (e.g., nurses, social workers, pharmacists, dietitians, and therapists) to broaden and deepen the assessment in a time-efficient manner (Table 7.2).



    • Incorporate key geriatric domains into the standard history and physical (rather than an “add-on”). With practice, this will allow for more focused and efficient care in the fast-paced hospital setting.


    7.4.1.4 Step 4: Avoid Misdiagnosis: Know About Unique Presentations of Common Conditions


    It is essential to maintain a high degree of skepticism and carefully re-evaluate the initial diagnosis of older patients admitted through the emergency department. Signs and symptoms due to adverse medication effects are often incorrectly ascribed to a medical or psychiatric problem. Up to 30 % of hospitalizations in the older population involve an adverse medication effect [19]. Although chest pain is the most common presenting symptom of acute coronary syndrome (ACS) in all ages, elderly patients often present with non-typical symptoms, including dyspnea, delirium, GERD, or fatigue [20]. In addition, ACS can be precipitated by other stresses, such as infection or dehydration, further delaying clinical recognition when the symptoms are non-classical. Older adults often have severe infection without fever or other typical signs and symptoms. Even in the setting of pneumonia or sepsis, fever is absent in 30–50 % of elderly patients [21]. Clinically, these infections present as non-specific symptoms of functional decline (abrupt change in self-care ability), a new geriatric syndrome (falls or delirium)—or exacerbation of an underlying chronic condition. There is often a recognized pattern to this common “atypical” presentation of acute illness, whereby the elder’s symptoms are reflective of the system with the least physiologic reserve (termed the “weakest-link principle”) [22].

    In addition, the presence of clinically significant chronic kidney disease is often missed (and medications incorrectly dosed) because of pseudo-normalization of the serum creatinine in older adults with low muscle mass and diminished renal function. To avoid this, renal function must be assessed by estimated glomerular filtration rate or creatinine clearance, rather than the MDRD that often appears in lab reports. Dementia or the new onset of acute confusion (delirium) interferes with obtaining a history and assessing symptoms. See Chap. 2 for a discussion of diagnosis and prevention of delirium. Lastly, the negative impact of ageism, combined with the absence of a reliable history, results in the inaccurate assumption of a terminal illness or advanced dementia in a malnourished, confused elderly patient who is suffering from an acute illness.

    Finally, a common conundrum for hospitalists: is the excessive information from imaging and laboratory assessments typically developed in a patient admitted through the emergency department. Seniors have many comorbidities and incidental findings. Therefore, often there are data that are irrelevant to the patient’s acute problem. Reviewing these data carefully and deciding what is important or irrelevant requires judgment and thoughtful communication with the patient and family but is important in developing a wise care plan and avoiding iatrogenic complications.



    • The interplay of normal age related physiological change, comorbidities, and geriatric syndromes results in heterogeneous, clinical presentations of common conditions. Overall, it’s essential to maintain a high index of suspicion for mis-diagnosis or under-diagnosis in the older adult.


    7.4.1.5 Step 5: Continuous Transition Planning: Begin on Admission


    Care transitions (often termed “handoffs,” “discharges,” or “transfers”) can be complicated and costly for older adults with complex needs, and planning for a safe and effective transition of care should begin on the day of admission. Care transitions occur between providers, between levels of care (e.g., from intensive care unit to the floor), or across healthcare settings (e.g., from hospital to a skilled-nursing facility, or hospital to home) and require several, well-orchestrated steps that address patient and family/caregiver, physician/healthcare provider, and health system factors [23]. While making every attempt to respect the patient’s autonomy and privacy, an important first step involves including caregivers and family members in the process.

    Elements of transition include care coordination, discharge planning, and disease management and hospitalists are responsible for the patient’s care from admission until the transition of care is complete. Hospitalists are encouraged by the National Transition of Care Coalition to adopt the concept of “transfer with continuous management” [24]. Unless a team-based, structured approach is utilized, key elements can get lost in the transition, resulting in highly fragmented and poor quality care. The transition plan should include a complete and clear medication list (reconciled with preadmission medication list), assessment of cognitive and functional level, lists of diagnoses, pending tests and appointments (and attention to logistical needs), assessment of caregiver needs and resources, and advance care directives. It should also include specific education regarding self-management, warning symptoms or signs (“red flags”) of their disease condition and who to call and what to do when these arise, instructions as to what to expect (including other clinical disciplines that may be involved in care, such as nursing or physical therapy), and how to navigate the next site of care (Table 7.3). At the time of any transition, a brief phone call between the current and receiving provider is very helpful.


    Table 7.3
    Improving care transitions for older adults






















    Discharge/transition barriers

    Recommended approaches

    Physician to provider communication

    • Collaborate with primary care provider (PCP) in discharge and follow-up planning

    • Promptly and accurately transfer information to the provider at the next level of care

    • Utilize a standardized template to ensure comprehensive communication

    • Communicate specifically about diagnoses, advance care plans, medications, allergies, adverse events, follow-up needs/pending tests and studies, red flags and possible next steps

    Medication management

    • Partner with clinical pharmacists to manage medication information and reconciliation, including over-the-counter products, and work to eliminate high risk medications for older adults (Chap. 5, Medication Management for Beers list)

    • Reconcile medications at all care transitions, and communicate list to PCP, including allergies and adverse medication events, and medications discontinued and added

    • Educate patients about changes to their medications, and develop a plan to ensure medication adherence for complex regimens

    Patient and family factors

    • Involve patient and family members early in the process of hospitalization

    • Work with interprofessional transfer/discharge teams to assess needs, and ensure available resources to optimize patient’s medical condition, functioning and safety, and to support the caregiver

    • Ensure that the patient and caregiver understand and agree with the goals and purpose of the transfer, and what to expect at next level of care

    • Assess the health literacy of patient and family, and provide access to patient care navigators to help negotiate the health system

    • Schedule and prepare for specific follow-up appointments prior to discharge

    • Utilize home health and/or hospice services when indicated, and consider home visits for high risk or frail elderly patients. Use established community networks and ensure coordination

    Physician–patient communication

    • Provide discharge counselling regarding diagnoses, medication changes, self-care instructions, appointments for follow-up, red flag symptoms, what to do if problems arise, and plans for durable medical equipment (if home)

    • Reaffirm patient’s goals of care, values, and preferences, and confirm advance care plans

    • Provide simply written materials with illustrations to reinforce verbal instructions and promote patient self-management

    • Utilize teach-back techniques to assess the gaps in patient and family’s understanding

    • Give opportunity to ask questions and spend time answering them

    • Encourage use of personal health record to manage information


    Adapted with permission from Sunil Kripalani, Amy T. Jackson, Jeffrey L. Schnipper, and Eric A. Coleman, Recommendations for improving care Transitions at Hospital Discharge, Journal of Hospital Medicine, Vol 2 No 5 Sept/Oct 2007 Page 316

    Suboptimal care transitions are hazardous to older adults and it impacts safety, costs, functional outcomes, morbidity, and mortality. Current high hospital readmission rates in part are a sobering reflection of our failures in transitional care, and a focus of national scrutiny. Nearly 20 % of Medicare beneficiaries are re-admitted within 30 days, and 30 % are readmitted within 90 days [25]. Risk for poor transitions in older adults include: living alone, limited self-care abilities, poor health literacy, low income, prior hospitalization, five or more comorbidities, functional impairments and limited resources or caregiver support, or transition to home with home-care services (because of the challenges involved in coordinating care at home for patients with complex needs). Specific diagnoses, including depression, heart disease, diabetes, and cancer, also predict poor transitions [26].

    Many problems occur if the hospitalists are not familiar with the capabilities of various settings , which include: home with family support, home with home-health care, custodial care (e.g., assisted living), skilled nursing facilities (SNF), acute rehabilitation hospital, long-term acute care (LTAC), and hospice care (home support or inpatient). Unless the hospitalist is familiar with resources at care settings, such as the availability of on-site medical care, specific medications, imaging or lab tests at SNF, the discharge plan may be unrealistic and unsustainable. It would be wise for hospitalists to briefly visit the most common community institutions used in his or her discharges to gain firsthand knowledge of their unique resources and limitations. Table 7.4 provides a synopsis of post-acute care services and institutions. For a planned discharge to home, access to ongoing medical care, cognitive or functional capabilities of the patient, availability of a caregiver, financial resources to pay for care, and the availability of community resources are especially important to consider. Ultimately, the choice of the discharge site of care should be the best match between the patient’s needs and the resources and services available at the location.
    Aug 25, 2017 | Posted by in GERIATRICS | Comments Off on Hospital Medicine

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