Introduction to Cancer Epidemiology
Fig. 5.1 John Snow Pub, Broadwick Road, London, UK The scope of epidemiology is much broader than the study of epidemics; it also involves the study of causal factors for all…
The Intersection of Epidemiology and Pathology
© Springer International Publishing Switzerland 2017Massimo Loda, Lorelei A. Mucci, Megan L. Mittelstadt, Mieke Van Hemelrijck and Maura Bríd Cotter (eds.)Pathology and Epidemiology of Cancer10.1007/978-3-319-35153-7_1 1. The Intersection of Epidemiology and Pathology Megan L. Mittelstadt1 , Edward L. Giovannucci2 , Lorelei A. Mucci3 and Massimo Loda4 (1)…
Molecular and Genetic Epidemiology of Cancer
Fig. 7.1 The left table shows six nucleotides from five individuals; three of these nucleotides vary and are therefore SNPs. From the right table, we can see that the two SNPs…
Tumor-Like Lesions of the Liver and Intrahepatic Bile Duct
Fig. 5.1 Focal nodular hyperplasia. (a) Mass magin is clear and the fibrous scar can be seen in the center of the lesion; (b) The color of the mass is…
Membrane Glycoproteins
Ligand Functions Copies/platelet Integrins αIIbβ3 (GPIIb-IIIa) Fibrinogen Aggregation, adhesion ~80,000 α2β1 (GPIa-IIa) Collagen Adhesion 3000–5000 α5β1 (VLA-5) Fibronectin Adhesion 1000 α6β1 (VLA-6) Laminin Adhesion 1000 αvβ3 Vitronectin Adhesion 100…
and Treatment of Primary Immune Thrombocytopenia in Children
Study No. of patients Age at ITP diagnosis (year) Duration before rituximab (month) Age at rituximab treatment (year) Times of injection Duration of observation (month) Rate of initial response (CR…
Diagnosis: Hypoplastic Thrombocytopenia
Decreased platelet production (hypoplastic thrombocytopenia) Aplastic anemia (AA) Amegakaryocytic thrombocytopenia Acute leukemia Chemotherapy-induced thrombocytopenia (CIT) Myelodysplastic syndrome (MDS) Malignancy with bone marrow infiltration or suppression (e.g., lymphoma, leukemia, solid tumors) Increased…
and Thrombopoiesis
Fig. 1 Megakaryopoiesis and thrombopoiesis. Differentiation from hematopoietic stem cells (HSCs) to platelets proceeds by a number of intermediate stages. Megakaryopoiesis contains stages from HSC to mature MKs in the…
Diagnosis: Congenital Macrothrombocytopenia
Platelet size Disease OMIM Inheritance Gene Features Small Wiskott-Aldrich syndrome 301000 X WAS Immunodeficiency X-linked thrombocytopenia 313900 X WAS No immunodeficiency FYB thrombocytopenia na AR FYB Activated platelets Normal ANKRD26…
