52.1 The bone remodeling system As transplantation osteoporosis results from alterations in the bone remodeling system, a review of normal bone remodeling is helpful to understanding the pathogenesis of this…
41.1 Introduction As a comorbidity of neurological disease, osteoporosis (OP) is often underdiagnosed, undertreated, or totally ignored in the face of more compelling circumstances that require immediate and continuous attention….
50.1 Introduction Diabetes mellitus is characterized by high levels of blood glucose; the main forms are type 1 diabetes (T1D), caused by a lack of insulin production due to an…
35.1 Skeletal muscle anatomy and physiology: an overview Chapters providing details about bone biology can be found in Section 35.3 . Here we will briefly review skeletal muscle anatomy and…
43.1 Celiac disease 43.1.1 Introduction Celiac disease is a chronic enteropathy in genetically predisposed individuals in response to gluten intake . Rather than being a rare and incurable disease, as…
37.1 Introduction Childhood and adolescence are critical periods for bone mass acquisition. Through skeletal growth, the peak of bone mineral accrual occurs approximately 6 months following the pubertal growth spurt,…
42.1 Introduction Iatrogenic bone loss and increased fracture risk caused by therapies for nonskeletal diseases is a growing and important cause of osteoporosis. The skeletal effects of glucocorticoids, progestins, excess…
25.1 Introduction Patients and many physicians still often misperceive osteoporosis as a typically female disorder. However, the male:female gender ratio for osteoporotic fractures is only about 1:1.6 , and for…
38.1 Introduction Osteoporosis occurs much less frequently in premenopausal women than in postmenopausal women. However, premenopausal osteoporosis can cause significant morbidity and premenopausal fractures are associated with increased risk of…
34.1 Introduction For decades the skeleton was viewed as a relatively isolated organ with little connection to other tissues in the body or to metabolic homeostasis. Certainly its role as…
