Keywords Herpes simplex virus, immunotherapy, oncolysis, advanced cancer, vaccine Introduction Recent advances in viral genome sequencing and elucidation of viral protein function combined with a better understanding of tumor…
Keywords Adenovirus, oncolytic, immunotherapy, patients, trials, ATAP, cancer, tumor, armed viruses Overview of Oncolytic Adenoviruses Gene therapy, as described in other chapters of this book, can be used in…
Keywords Oncolytic virotherapy, brain tumors, gliomas, adenoviruses, autophagy, therapy, cancer Introduction Oncolytic virotherapy utilizes the ability of replicating viruses to selectively infect malignant cells, replicate within them, and subsequently…
Keywords Adoptive immunotherapy, dendritic cells, electropermeabilization, gene delivery systems, gene editing, gene silencing, gene transfer, hematopoietic, lentiviral vectors, LTR, mesenchymal stem cells, mitochondrion gene therapy, pseudotyping, retroviral vectors, RNAi, RRE,…
Fig. 5.1 Simple thyroid cyst Fig. 5.2 Colloid cystic nodule Another pattern to recognize as a benign nodule is the “spongiform nodule” also described in the literature as honeycomb or…
Fig. 7.1 Benign macrofollicular cluster with uniform, evenly spaced nuclei Fig. 7.2 Benign macrofollicular clusters and pools of colloid from a benign thyroid nodule aspirate Fig. 7.3 Mixture of histiocytes…
Radionuclide Half-life Main emission Radiopharmaceutical Clinical use or relevance to thyroid nodules 123I 13 h Gamma [123I] NaI Scintigraphy and iodine uptake 124I 4 d Gamma and positron [124I] NaI…
Fig. 12.1 High suspicion thyroid nodule with hypoechoic appearance and microcalcifications Fig. 12.2 Intermediate suspicion thyroid nodule with hypoechoic appearance and smooth borders Fig. 12.3 Low suspicion thyroid nodule with…
Study (location, year) MNG SN Diagnostic method OR (CI) Events Population Events Population Abu-Eshy et al. (Saudi Arabia, 1995) 14 172 16 105 Surgery 0.49 (0.23–1.06) Belfiore et al. (Italy,…
Syndrome Gene Chromosomal location Inheritance Type of cancer Other features Isolated FMTC [151] RET 10q11.2 AD MTC MEN2A [151] RET 10q11.2 AD MTC Pheochromocytoma, hyperparathyroidism MEN2B [151] RET 10q11.2 AD…
