Outline Hydatidiform Mole Epidemiology Cytogenetics and Pathology Presentation and Symptoms Diagnosis Evacuation Risk Factors for Postmolar Gestational Trophoblastic Neoplasia Postmolar Surveillance Prophylactic Chemotherapy After Molar Evacuation Coexistent Molar Pregnancy With…
Outline Introduction Clinical Presentation Endometrial Hyperplasia: Pathologic Diagnostic Criteria Management Decisions for Atypical Endometrial Hyperplasia (Endometrial Intraepithelial Neoplasia) Management of Endometrial Hyperplasia Without Atypia Prevention of Endometrial Cancer Benefits and…
Outline Classification Incidence and Epidemiology Leiomyosarcoma Clinical Profile Surgical Management Adjuvant Therapy Management of Recurrent Disease Endometrial Stromal Sarcoma Clinical Profile Surgical Management Adjuvant Therapy Management of Recurrent Disease Other…
Outline Natural History Epidemiology Human Papillomavirus Vaccination Screening Core Principles for Managing Abnormal Screening Test Results Managing Abnormal Cervical Cancer Screening Test Results Managing Abnormal Results in Young Women Unsatisfactory…
Outline Embryology Examination and Treatment of Females Exposed to Diethylstilbestrol Nonneoplastic Epithelial Disorders of the Vulva Lichen Simplex Chronicus Lichen Sclerosus Lichen Planus Diagnosis and Treatment Intraepithelial Neoplasia of the…
Abstract Growth hormone (GH) insensitivity can result from molecular defects at multiple levels, including the genes for the GH receptor ( GHR ), signal transducer and activator of transcription (…
Abstract Since completion of the Human Genome Project in 2001, dynamics in human genetics have greatly accelerated. Sequencing a human genome used to be a multimillion dollar project but is…
Abstract Diagnosing monogenic forms of diabetes provides an opportunity to deliver personalized genetic medicine. The most common monogenic causes of diabetes can be treated with therapeutic options targeted to genetic…
Abstract Whole genome sequencing is not at present cost-effective in most settings. But today’s molecular genetic laboratory can effectively sequence panels of several hundred genes, and even entire exomes without…
Abstract This chapter addresses the role of genetic counseling in the diagnosis of hereditary syndromes, particularly hereditary endocrine diseases. Genetic counseling is a communication process that encompasses risk assessment, informed…
