Chapter Outline PATHOLOGIC CLASSIFICATION OF RHABDOMYOSARCOMA RHABDOMYOSARCOMA IN CANCER PREDISPOSITION SYNDROMES GENETICS OF SPORADIC RHABDOMYOSARCOMA Gene Fusions Generated by Chromosomal Rearrangements Chromosome Copy Number Changes Amplification of Specific Chromosomal Regions…
Chapter Outline PRINCIPLES OF RADIATION ONCOLOGY THE PHYSICAL BASIS OF RADIOTHERAPY RADIOBIOLOGY Mechanisms of Radiation Damage Clonogenic Survival Curves The Oxygen Effect Radiation Interactions with Chemotherapeutic Agents TECHNOLOGICAL ADVANCES IN…
Chapter Outline ACUTE MYELOGENOUS LEUKEMIA Epidemiology and Etiology Biology Molecular Genetics Morphology and Cytochemistry Immunophenotype Cytogenetics Clinical Presentation Treatment Prognosis Minimal Residual Disease Relapsed or Refractory Disease ACUTE PROMYELOCYTIC LEUKEMIA…
Chapter Outline EPIDEMIOLOGY BIOLOGY OF RETINOBLASTOMA Cellular Origins of Retinoblastoma Retinoblastoma Tumor Cell Differentiation Retinoblastoma Genomics and Epigenomics Retinoblastoma Preclinical Models Retinoblastoma Translational Research GENETIC COUNSELING FOR FAMILIES WITH RETINOBLASTOMA…
Chapter Outline KEY COMPONENTS OF THE IMMUNE SYSTEM AND THEIR RELEVANCE IN CANCER IMMUNOTHERAPY Humoral Arm of the Immune System Cellular Arm of the Immune System TARGET ANTIGENS IN CANCER…
Chapter Outline PATHOLOGY OF PEDIATRIC RENAL TUMORS Staging Wilms Tumor (Nephroblastoma) Clear Cell Sarcoma of the Kidney Congenital Mesoblastic Nephroma Malignant Rhabdoid Tumor of the Kidney Renal Carcinomas in Children…
Chapter Outline EPIDEMIOLOGY PATHOGENESIS Embryology Development of the Sympathetic Nervous System Genetic Disorders Associated with Neuroblastoma Neuroblastoma Stem Cells Hereditary Predisposition to Neuroblastoma Genetic Aberrations in Sporadic Neuroblastoma Chromosomal Abnormalities…
Chapter Outline COLLAGEN DISORDERS Collagen Vascular Disease Vasculitis Connective Tissue Disorders INFECTIOUS DISEASES General Hematologic Signs of Infection Hematologic Aspects of Specific Infections CARDIAC DISEASE Hemolysis Acquired Coagulation Abnormalities Platelet…
Chapter Outline CHEMOTHERAPEUTIC AGENTS CLINICAL APPLICATION OF CHEMOTHERAPY CHEMOTHERAPY IN CHILDREN PHARMACOKINETIC CHANGES DURING CHILDHOOD Absorption Volume of Distribution Hepatic Metabolism Renal and Hepatic Excretion Influence of Underlying Disease on…
Chapter Outline CLASSIFICATION Morphologic and Cytochemical Classification Immunophenotype MOLECULAR PATHOGENESIS Transcriptional Regulators Growth Factor Signaling Molecular Pathogenesis of Select High-Risk Subtypes CLINICAL MANIFESTATIONS Peripheral Blood Bone Marrow Extramedullary Leukemia DIFFERENTIAL…
