Role of Innate Immunity in Cancers and Antitumor Response
Fig. 3.1 Role of innate immune receptors in the regulation of antitumor immunity. (a) The functions of the innate immune system are regulated by various receptors expressed in immune cells….
Regulatory T Cells and Th17 Cells in Cancer Microenvironment
Fig. 6.1 Potential roles of FoxP3+ T cells and Th17 cells in tumors. (a) FoxP3+ T cells are made in the thymus as naïve-type FoxP3+ T cells, which migrate to…
Inflammatory and Innate Immune Cells in Cancer Microenvironment and Progression
Fig. 2.1 Differentiation pathways of tumor-associated myeloid cells. Myeloid cells originate from hematopoietic stem cells (HSC) in the bone marrow. Here the networks that give rise to the various myeloid…
Introduction on Cancer Immunology and Immunotherapy
© Springer-Verlag Berlin Heidelberg 2015Nima Rezaei (ed.)Cancer Immunology10.1007/978-3-662-44006-3_1 1. Introduction on Cancer Immunology and Immunotherapy Nima Rezaei1, 2 , Seyed Hossein Aalaei-Andabili3, 4 and Howard L. Kaufman5 (1) Department of Immunology, Research Center for Immunodeficiencies, Children’s Medical Center, Pediatrics Center…
Oncogenic Role of Hepatitis B Virus
Fig. 1 The hepatitis B virus genome and the covalently closed circular DNA (cccDNA). The viral genome (left panel) is made of two linear DNA strands maintained in circular configuration by…
and Leukemogenesis: Virus–Cell Interactions in the Development of Adult T-Cell Leukemia
Fig. 1 A multireceptor model for HTLV-1 entry. HSPG = heparan sulfate proteoglycans; SU = the subunit of HTLV-1 envelope glycoprotein; NRP-1 = neuropilin-1; GLUT-1 = glucose transporter 1; CTD = C-terminal domain; RBD = receptor-binding domain; PRR = proline-rich region. This drawing is modified…
Biology of Human Herpesvirus 8: Novel Functions and Virus–Host Interactions Implicated in Viral Pathogenesis and Replication
Fig. 1 ER-localized interactions and activities of vIL-6 in latently infected PEL cells. In the context of PEL latency, vIL-6 is expressed at low but functional levels and is largely sequestered…
of Virus Infection and Human Cancer
Virus Cancer sites with sufficient evidence Cancer sites with limited evidence Epstein–Barr virus (EBV) Nasopharyngeal carcinoma, Burkitt’s lymphoma, immune suppression-related non-Hodgkin lymphoma, extranodal NK/T cell lymphoma (nasal type), Hodgkin’s lymphoma…
Oncogenic Role of Hepatitis C Virus
Fig. 1 The structure of hepatitis C virus genome. The HCV genome RNA encodes a polyprotein of 3,010 a.a., which is processed into structural and non-structural proteins by the cellular or…
of Hepatitis B Virus Infection and Liver Cancer
Risk factors High risk/low risk References Viral factors 1. HBsAg Positive/negative = 66/1 Beasley et al. (1981) 2. HBeAg in HBsAg-positive persons Positive/negative = 60/10 Yang et al. (2002) 3. HBV DNA level…
